ArticleGastroenterology research and practice2009
Prognostic value of microvascular density in dukes a and B (t1-t4, n0, m0) colorectal carcinomas.
Article in Gastroenterology research and practice, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Role of VEGF, CD105, and CD31 in the Prognosis of Colorectal Cancer Cases.Journal of gastrointestinal cancer · 2019Article
- Increased chemoresistance via Snail-Raf kinase inhibitor protein signaling in colorectal cancer in response to a nicotine derivative.Oncotarget · 2016Article
- Recurrences in stage II rectal carcinoma after curative resection alone: from the viewpoint of angiogenesis.World journal of surgical oncology · 2016Article
- Prognostic Significance of Microvessel Density Determining by Endoglin in Stage II Rectal Carcinoma: A Retrospective Analysis.Gastroenterology research and practice · 2015Article
- Quantification of tumour budding, lymphatic vessel density and invasion through image analysis in colorectal cancer.Journal of translational medicine · 2014Article
- Polymorphisms in XPD and ERCC1 Associated with Colorectal Cancer Outcome.International journal of molecular sciences · 2013Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAproximatelly 30% of patients operated on for colorectal cancer (CRC), with an expectedly favourable prognosis (Dukes A-B/T1-T4, N0, M0) suffer recurrence and/or die.
methodIn order to determine if tumor microvascular density (MVD) is a prognostic factor in CRC, samples from tumors of 104 Dukes A-B CRC patients were retrospectively studied. Immunohistochemistry was performed for anti-CD34 antibody to visualize tumor vascularisation. MVD was expressed as the total number of vessels and as the percentage of microvascular area. We calculated MVD with a morphometry program and performed descriptive, bivariate, and survival statistics.
resultsThe mean number of vessels was 37.37/200x field, and the mean vascular area was the 3.972%. 30% of the patients with < 37 vessels/field, and 21% of the patients with > 37 vessels/field, experienced recurrence/death. The 35% of patients with < 4% of vascular area died following recurrence, compared with 14% of patients with > or =4% of vascular area. These differences in % of vascular area were statistically significant.
conclusionMVD expressed as the total number of vessels had no a statistically significant influence on the evolution of CRC. However, neoplasias with a greater % of vascular were associated to a better outcome.
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Registered trials
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