ArticlePLoS biology2009
Cadherin-2 controls directional chain migration of cerebellar granule neurons.
Article in PLoS biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
41 citing papers in PubMed, 86 citations in OpenAlex.
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- Lifelong regeneration of cerebellar Purkinje cells after induced cell ablation in zebrafish.eLife · 2023Article
- Endoglycan Regulates Purkinje Cell Migration by Balancing Cell-Cell Adhesion.Frontiers in neuroscience · 2022Article
- Altering Cell-Cell Interaction in Prenatal Alcohol Exposure Models: Insight on Cell-Adhesion Molecules During Brain Development.Frontiers in molecular neuroscience · 2021Review
- Microtubules and motor proteins support zebrafish neuronal migration by directing cargo.The Journal of cell biology · 2020Article
- Netrin-1 promotes the collective cell migration of liver cancer cells in a 3D cell culture model.Journal of physiology and biochemistry · 2019Article
- NEGR1 and FGFR2 cooperatively regulate cortical development and core behaviours related to autism disorders in mice.Brain : a journal of neurology · 2018Article
- IKKα regulates human keratinocyte migration through surveillance of the redox environment.Journal of cell science · 2017Article
- Adult Neurogenesis in Fish.Cold Spring Harbor perspectives in biology · 2016Review
- Cadherin-2 Is Required Cell Autonomously for Collective Migration of Facial Branchiomotor Neurons.PloS one · 2016Article
- Capturing tissue repair in zebrafish larvae with time-lapse brightfield stereomicroscopy.Journal of visualized experiments : JoVE · 2015Article
- N-cadherin-based adherens junction regulates the maintenance, proliferation, and differentiation of neural progenitor cells during development.Cell adhesion & migration · 2015Review
- Cadherins as regulators of neuronal polarity.Cell adhesion & migration · 2015Review
- Rare autosomal copy number variations in early-onset familial Alzheimer's disease.Molecular psychiatry · 2014Article
- Small Rho GTPases in the control of cell shape and mobility.Cellular and molecular life sciences : CMLS · 2014Review
- Article
- Regulation of cadherin expression in nervous system development.Cell adhesion & migration · 2014Review
- N-cadherin sustains motility and polarity of future cortical interneurons during tangential migration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Long distance migration of differentiating granule cells from the cerebellar upper rhombic lip has been reported in many vertebrates. However, the knowledge about the subcellular dynamics and molecular mechanisms regulating directional neuronal migration in vivo is just beginning to emerge. Here we show by time-lapse imaging in live zebrafish (Danio rerio) embryos that cerebellar granule cells migrate in chain-like structures in a homotypic glia-independent manner. Temporal rescue of zebrafish Cadherin-2 mutants reveals a direct role for this adhesion molecule in mediating chain formation and coherent migratory behavior of granule cells. In addition, Cadherin-2 maintains the orientation of cell polarization in direction of migration, whereas in Cadherin-2 mutant granule cells the site of leading edge formation and centrosome positioning is randomized. Thus, the lack of adhesion leads to impaired directional migration with a mispositioning of Cadherin-2 deficient granule cells as a consequence. Furthermore, these cells fail to differentiate properly into mature granule neurons. In vivo imaging of Cadherin-2 localization revealed the dynamics of this adhesion molecule during cell locomotion. Cadherin-2 concentrates transiently at the front of granule cells during the initiation of individual migratory steps by intramembraneous transport. The presence of Cadherin-2 in the leading edge corresponds to the observed centrosome orientation in direction of migration. Our results indicate that Cadherin-2 plays a key role during zebrafish granule cell migration by continuously coordinating cell-cell contacts and cell polarity through the remodeling of adherens junctions. As Cadherin-containing adherens junctions have been shown to be connected via microtubule fibers with the centrosome, our results offer an explanation for the mechanism of leading edge and centrosome positioning during nucleokinetic migration of many vertebrate neuronal populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.