ArticleGenome research2009
Epidemic multiple drug resistant Salmonella Typhimurium causing invasive disease in sub-Saharan Africa have a distinct genotype.
Article in Genome research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 361 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
361 citing papers in PubMed, 5 syntheses or guidelines pooled it, 553 citations in OpenAlex.
- Presence of integrons and their correlation with multidrug resistance in Salmonella enterica serovar Typhimurium: Exploratory systematic reviewBiomedica : revista del Instituto Nacional de Salud · 2024Pooled it
- Pooled it
- Trends in horizontal gene transfer research inFrontiers in microbiology · 2024Pooled it
- The global burden of non-typhoidal salmonella invasive disease: a systematic analysis for the Global Burden of Disease Study 2017.The Lancet. Infectious diseases · 2019Pooled it
- Molecular epidemiology of fluoroquinolone resistant Salmonella in Africa: A systematic review and meta-analysis.PloS one · 2018Pooled it
- A combination typhoid and non-typhoidal Salmonella polysaccharide conjugate vaccine in healthy adults: a randomized, placebo-controlled phase 1 trial.Nature medicine · 2025Trial
- The miR-744-5p/connexin 43 axis modulates Salmonella-containing vacuole association with the Golgi network.The EMBO journal · 2026Article
- Decoupling virulence from growth: a synthetic α-helical peptide suppressesMicrobiology spectrum · 2026Article
- The presence of the dam gene is important for the proliferation of Salmonella Typhimurium in egg yolk.Poultry science · 2026Article
- Whole-Genome Sequencing-Based Characterisation ofMicroorganisms · 2026Article
- Pan genome clustering identifies a novel mosaic prophage specific to Salmonella Enteritidis lineage associated with the invasive disease in India.PLoS neglected tropical diseases · 2026Article
- Public health data collected by PulseNet support a role forMicrobiology spectrum · 2026Article
- Exploring bet-hedging inmSystems · 2026Article
- Host adaptation inApplied and environmental microbiology · 2026Review
- Distinct genomic trajectory among invasive Salmonella Typhimurium ST313 infections.Nature communications · 2026Article
- Current Applications and Immunological Considerations ofMicroorganisms · 2026Review
- Infection strategies ofGut microbes reports · 2026Review
- Genomic and epidemiologic evidence for attenuated virulence inFrontiers in microbiology · 2026Article
- Development of a GMMA-based candidate vaccine against invasive nontyphoidalFrontiers in immunology · 2026Article
- Unravelling the Pathotype, Biofilm, Virulome and Resistome Profile of MultiDrug-Resistant Bacteria Isolated From Cattle Faeces Using Whole Genome Sequence Analysis.International journal of microbiology · 2026Article
301 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 6 institutions in 5 countries.
Funding
Abstract
Whereas most nontyphoidal Salmonella (NTS) are associated with gastroenteritis, there has been a dramatic increase in reports of NTS-associated invasive disease in sub-Saharan Africa. Salmonella enterica serovar Typhimurium isolates are responsible for a significant proportion of the reported invasive NTS in this region. Multilocus sequence analysis of invasive S. Typhimurium from Malawi and Kenya identified a dominant type, designated ST313, which currently is rarely reported outside of Africa. Whole-genome sequencing of a multiple drug resistant (MDR) ST313 NTS isolate, D23580, identified a distinct prophage repertoire and a composite genetic element encoding MDR genes located on a virulence-associated plasmid. Further, there was evidence of genome degradation, including pseudogene formation and chromosomal deletions, when compared with other S. Typhimurium genome sequences. Some of this genome degradation involved genes previously implicated in virulence of S. Typhimurium or genes for which the orthologs in S. Typhi are either pseudogenes or are absent. Genome analysis of other epidemic ST313 isolates from Malawi and Kenya provided evidence for microevolution and clonal replacement in the field.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.