ArticleThe Journal of biological chemistry2010
Soluble Nogo receptor down-regulates expression of neuronal Nogo-A to enhance axonal regeneration.
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 28 citations in OpenAlex.
- The Role of DNA Methylation in Stroke Recovery.International journal of molecular sciences · 2022Review
- Dorsal Root Injury-A Model for Exploring Pathophysiology and Therapeutic Strategies in Spinal Cord Injury.Cells · 2021Review
- Article
- Regulatable Transgene Expression for Prevention of Chemotherapy-Induced Peripheral Neuropathy.Molecular therapy. Methods & clinical development · 2017Article
- Multiple uses of fibrin sealant for nervous system treatment following injury and disease.The journal of venomous animals and toxins including tropical diseases · 2017Review
- Effects of Gualou Guizhi Decoction Aqueous Extract on Axonal Regeneration in Organotypic Cortical Slice Culture after Oxygen-Glucose Deprivation.Evidence-based complementary and alternative medicine : eCAM · 2017Article
- NT-3 promotes proprioceptive axon regeneration when combined with activation of the mTor intrinsic growth pathway but not with reduction of myelin extrinsic inhibitors.Experimental neurology · 2016Article
- Expressing Constitutively Active Rheb in Adult Dorsal Root Ganglion Neurons Enhances the Integration of Sensory Axons that Regenerate Across a Chondroitinase-Treated Dorsal Root Entry Zone Following Dorsal Root Crush.Frontiers in molecular neuroscience · 2016Article
- HspB1 silences translation of PDZ-RhoGEF by enhancing miR-20a and miR-128 expression to promote neurite extension.Molecular and cellular neurosciences · 2013Article
- Methylprednisolone inhibits Nogo-A protein expression after acute spinal cord injury.Neural regeneration research · 2013Article
- Gray matter is targeted in first-attack multiple sclerosis.PloS one · 2013Article
- HSV-mediated gene transfer of C3 transferase inhibits Rho to promote axonal regeneration.Experimental neurology · 2012Article
- Hippocampal expression of myelin-associated inhibitors is induced with age-related cognitive decline and correlates with deficits of spatial learning and memory.Journal of neurochemistry · 2012Article
- Reduction of voltage gated sodium channel protein in DRG by vector mediated miRNA reduces pain in rats with painful diabetic neuropathy.Molecular pain · 2012Article
- Sensory axon regeneration: rebuilding functional connections in the spinal cord.Trends in neurosciences · 2012Review
- Neuronal Nogo-A regulates glutamate receptor subunit expression in hippocampal neurons.Journal of neurochemistry · 2011Article
- Rho GTPase regulation of α-synuclein and VMAT2: implications for pathogenesis of Parkinson's disease.Molecular and cellular neurosciences · 2011Article
- Prevention of diabetic neuropathy by regulatable expression of HSV-mediated erythropoietin.Molecular therapy : the journal of the American Society of Gene Therapy · 2011Article
- Article
- Guidance molecules in axon regeneration.Cold Spring Harbor perspectives in biology · 2010Review
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Nogo-A, a member of the reticulon family, is present in neurons and oligodendrocytes. Nogo-A in central nervous system (CNS) myelin prevents axonal regeneration through interaction with Nogo receptor 1, but the function of Nogo-A in neurons is less known. We found that after axonal injury, Nogo-A is increased in dorsal root ganglion (DRG) neurons unable to regenerate following a dorsal root injury or a sciatic nerve ligation-cut injury and that exposure in vitro to CNS myelin dramatically enhanced neuronal Nogo-A mRNA and protein through activation of RhoA while inhibiting neurite growth. Knocking down neuronal Nogo-A by small interfering RNA results in a marked increase of neurite outgrowth. We constructed a nonreplicating herpes simplex virus vector (QHNgSR) to express a truncated soluble fragment of Nogo receptor 1 (NgSR). NgSR released from QHNgSR prevented myelin inhibition of neurite extension by hippocampal and DRG neurons in vitro. NgSR prevents RhoA activation by myelin and decreases neuronal Nogo-A. Subcutaneous inoculation of QHNgSR to transduce DRG neurons resulted in improved regeneration of myelinated fibers in both the dorsal root and the spinal dorsal root entry zone, with concomitant improvement in sensory behavior. The results indicate that neuronal Nogo-A is an important intermediate in neurite growth dynamics and its expression is regulated by signals related to axonal injury and regeneration, that CNS myelin appears to activate signaling events that mimic axonal injury, and that NgSR released from QHNgSR may be used to improve recovery after injury.
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