ArticleNucleic acids research2010
dbDEPC: a database of differentially expressed proteins in human cancers.
Article in Nucleic acids research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- dbGENVOC: database of GENomic Variants of Oral Cancer, with special reference to India.Database : the journal of biological databases and curation · 2021Article
- ANPELA: analysis and performance assessment of the label-free quantification workflow for metaproteomic studies.Briefings in bioinformatics · 2020Article
- Therapeutic target database 2020: enriched resource for facilitating research and early development of targeted therapeutics.Nucleic acids research · 2020Article
- In silico prediction of cancer immunogens: current state of the art.BMC immunology · 2018Review
- DEXTER: Disease-Expression Relation Extraction from Text.Database : the journal of biological databases and curation · 2018Article
- dbDEPC 3.0: the database of differentially expressed proteins in human cancer with multi-level annotation and drug indication.Database : the journal of biological databases and curation · 2018Article
- Human cancer databases (review).Oncology reports · 2015Review
- Molecular Recognition of Human Liver Cancer Cells Using DNA Aptamers Generated via Cell-SELEX.PloS one · 2015Article
- Bioinformatics for cancer immunology and immunotherapy.Cancer immunology, immunotherapy : CII · 2012Review
- CIDeR: multifactorial interaction networks in human diseases.Genome biology · 2012Article
- dbDEPC 2.0: updated database of differentially expressed proteins in human cancers.Nucleic acids research · 2012Article
- SyStemCell: a database populated with multiple levels of experimental data from stem cell differentiation research.PloS one · 2012Article
- Liverome: a curated database of liver cancer-related gene signatures with self-contained context information.BMC genomics · 2011Article
- Biomarkers of metastatic potential in cultured adenocarcinoma clones.Clinical & experimental metastasis · 2011Article
- dbDEMC: a database of differentially expressed miRNAs in human cancers.BMC genomics · 2010Article
- Integrating the multiple dimensions of genomic and epigenomic landscapes of cancer.Cancer metastasis reviews · 2010Review
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Authors and funding
6 authors.
Funding
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Abstract
Cancer-related investigations have long been in the limelight of biomedical research. Years of effort from scientists and doctors worldwide have generated large amounts of data at the genome, transcriptome, proteome and even metabolome level, and DNA and RNA cancer signature databases have been established. Here we present a database of differentially expressed proteins in human cancers (dbDEPC), with the goal of collecting curated cancer proteomics data, providing a resource for information on protein-level expression changes, and exploring protein profile differences among different cancers. dbDEPC currently contains 1803 proteins differentially expressed in 15 cancers, curated from 65 mass spectrometry (MS) experiments in peer-reviewed publications. In addition to MS experiments, low-throughput experiment data from the same literatures and cancer-associated genes from external databases were also integrated to provide some validation information. Furthermore, dbDEPC associates differential proteins with important structural variations in the human genome, such as copy number variations or single nucleotide polymorphisms, which might be helpful for explaining changes in protein expression at the DNA level. Data in dbDEPC can be queried by protein identifier, description or sequence; the retrieved protein entry provides the differential expression pattern seen in cancers, along with detailed annotations. dbDEPC is expected to be a reference database for cancer signatures at the protein level. This database is provided at http://dbdepc.biosino.org/index/.
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