ArticleCancer letters2010
Silibinin inhibits ethanol metabolism and ethanol-dependent cell proliferation in an in vitro model of hepatocellular carcinoma.
Article in Cancer letters, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 50 citations in OpenAlex.
- Effects of soluble epoxide hydrolase inhibition on liver injury and gut microbiota in mice chronically fed ethanol.Alcohol, clinical & experimental research · 2025Article
- Novel Strategies Enhancing Bioavailability and Therapeutical Potential of Silibinin for Treatment of Liver Disorders.Drug design, development and therapy · 2024Review
- Ellagic Acid Prevents Binge Alcohol-Induced Leaky Gut and Liver Injury through Inhibiting Gut Dysbiosis and Oxidative Stress.Antioxidants (Basel, Switzerland) · 2021Article
- Changes in Glutathione Content in Liver Diseases: An Update.Antioxidants (Basel, Switzerland) · 2021Review
- Acrylamide induces HepG2 cell proliferation through upregulation of miR-21 expression.Journal of biomedical research · 2019Article
- Use of a crossed high alcohol preferring (cHAP) mouse model with the NIAAA-model of chronic-binge ethanol intake to study liver injury.Alcohol and alcoholism (Oxford, Oxfordshire) · 2017Article
- Evaluation of HepaRG cells for the assessment of indirect drug-induced hepatotoxicity using INH as a model substance.Human cell · 2017Article
- Silibinin Prevents Autophagic Cell Death upon Oxidative Stress in Cortical Neurons and Cerebral Ischemia-Reperfusion Injury.Molecular neurobiology · 2016Article
- Role of alcohol in the development and progression of hepatocellular carcinoma.Hepatic oncology · 2016Review
- Behavioral and Neurochemical Deficits in Aging Rats with Increased Neonatal Iron Intake: Silibinin's Neuroprotection by Maintaining Redox Balance.Frontiers in aging neuroscience · 2015Article
- Diet-induced obesity and ethanol impair progression of hepatocellular carcinoma in a mouse mesenteric vein injection model.Surgical endoscopy · 2013Article
- Silibinin (Milk Thistle) potentiates ethanol-dependent hepatocellular carcinoma progression in male mice.Cancer letters · 2012Article
- Inhibition of silibinin on migration and adhesion capacity of human highly metastatic breast cancer cell line, MDA-MB-231, by evaluation of β1-integrin and downstream molecules, Cdc42, Raf-1 and D4GDI.Medical oncology (Northwood, London, England) · 2012Article
- Chronic ethanol feeding accelerates hepatocellular carcinoma progression in a sex-dependent manner in a mouse model of hepatocarcinogenesis.Alcoholism, clinical and experimental research · 2012Article
- Alcohol induces liver neoplasia in a novel alcohol-preferring rat model.Alcoholism, clinical and experimental research · 2011Article
- Altered expression and function of regulator of G-protein signaling-17 (RGS17) in hepatocellular carcinoma.Cellular signalling · 2011Article
- Targeting collagen expression in alcoholic liver disease.World journal of gastroenterology · 2011Review
- Differential in vitro effects of intravenous versus oral formulations of silibinin on the HCV life cycle and inflammation.PloS one · 2011Article
- Antimetastatic efficacy of silibinin: molecular mechanisms and therapeutic potential against cancer.Cancer metastasis reviews · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Chronic ethanol consumption is a known risk factor for developing hepatocellular carcinoma (HCC). The use of plant-derived antioxidants is gaining increasing clinical prominence as a potential therapy to ameliorate the effects of ethanol on hepatic disease development and progression. This study demonstrates silibinin, a biologically active flavanoid derived from milk thistle, inhibits cytochrome p4502E1 induction, ethanol metabolism and reactive oxygen species generation in HCC cells in vitro. These silibinin-mediated effects also inhibit ethanol-dependent increases in HCC cell proliferation in culture.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.