Evidence map›Paper›PMID 19900496›Full record

ReviewAdvanced drug delivery reviews2010

Modified natural nanoparticles as contrast agents for medical imaging.

David P Cormode, Peter A Jarzyna, Willem J M Mulder, Zahi A Fayad

Abstract readReview
In one paragraph

Review in Advanced drug delivery reviews, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed.

  1. Tantalum-Based Nanomaterials: From Properties to Biomedical Applications.Advanced materials (Deerfield Beach, Fla.) · 2026
    Review
  2. Contrast Agents for Enhanced Bioimaging: A Comprehensive Review.Chembiochem : a European journal of chemical biology · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Biomimetic cell membrane-coated poly(lactic-Bioengineering & translational medicine · 2023
    Review
  11. Nanomaterial-based contrast agents.Nature reviews. Methods primers · 2023
    Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Current Advances in 3D Tissue and Organ Reconstruction.International journal of molecular sciences · 2021
    Review
  18. Review
  19. AnJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2020
    Article
  20. Review

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

David P CormodeTranslational and Molecular Imaging Institute, Mount Sinai School of Medicine, New York, NY 10029, USA.
Peter A Jarzyna
Willem J M Mulder
Zahi A Fayad

Funding

MR/PET Imaging of coronary atherosclerosisR01HL071021 · NHLBI · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI FAYAD, ZAHI A. · 2002 to 2019
$7.8M
Theranostic HDL nanoparticles for inflammatory macrophages in atherosclerosisR01EB009638 · NIBIB · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI FAYAD, ZAHI A. · 2009 to 2016
$4.6M
Nanoparticles for Molecular MRI of AtherosclerosisR01HL078667 · NHLBI · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI FAYAD, ZAHI A. · 2004 to 2008
$2.5M
NHLBI NIH HHS R01 HL071021NHLBI NIH HHS R01 HL078667NHLBI NIH HHS R01 HL71021NHLBI NIH HHS R01 HL78667NIBIB NIH HHS R01 EB009638
6 · The paper itself

Abstract

The development of novel and effective contrast agents is one of the drivers of the ongoing improvement in medical imaging. Many of the new agents reported are nanoparticle-based. There are a variety of natural nanoparticles known, e.g. lipoproteins, viruses or ferritin. Natural nanoparticles have advantages as delivery platforms such as biodegradability. In addition, our understanding of natural nanoparticles is quite advanced, allowing their adaptation as contrast agents. They can be labeled with small molecules or ions such as Gd(3+) to act as contrast agents for magnetic resonance imaging, (18)F to act as positron emission tomography contrast agents or fluorophores to act as contrast agents for fluorescence techniques. Additionally, inorganic nanoparticles such as iron oxide, gold nanoparticles or quantum dots can be incorporated to add further contrast functionality. Furthermore, these natural nanoparticle contrast agents can be re-routed from their natural targets via the attachment of targeting molecules. In this review, we discuss the various modified natural nanoparticles that have been exploited as contrast agents.

Indexed as

NanoparticlesAnimalsContrast MediaDiagnostic ImagingFerritinsHumansLipoproteinsNanotechnologyVirusesContrast MediaFerritinsLipoproteins

Identifiers

PMID19900496
PMCPMC2827667

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.