ArticleMedical & biological engineering & computing2009
Composition of the pericellular matrix modulates the deformation behaviour of chondrocytes in articular cartilage under static loading.
Article in Medical & biological engineering & computing, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 53 citations in OpenAlex.
- A deep neural network-enhanced multi-scale coupled model of patient-specific acoustic wave propagation for mechanotransduction stimulation of healthy and osteoarthritic knee articular cartilage.Biomechanics and modeling in mechanobiology · 2026Article
- A multiscale modeling approach to study the role of mechanics and inflammation in the pathophysiology of articular cartilage.Computers in biology and medicine · 2026Article
- Role of collagen VI and IX in mechanotransduction in the cartilage microenvironments: A multiscale in silico examination.Journal of orthopaedic translation · 2026Article
- Biomechanics of Chondrocytes and Chondrons in Healthy Conditions and Osteoarthritis: A Review of the Mechanical Characterisations at the Microscale.Biomedicines · 2023Review
- Changes in stiffness of the extracellular and pericellular matrix in the anulus fibrosus of lumbar intervertebral discs over the course of degeneration.Frontiers in bioengineering and biotechnology · 2022Article
- Combination of chondrocytes and chondrons improves extracellular matrix production to promote the repairs of defective knee cartilage in rabbits.Journal of orthopaedic translation · 2021Article
- Early changes in cartilage pericellular matrix micromechanobiology portend the onset of post-traumatic osteoarthritis.Acta biomaterialia · 2020Article
- Numerical Study on Electromechanics in Cartilage Tissue with Respect to Its Electrical Properties.Tissue engineering. Part B, Reviews · 2019Review
- Influence of the pericellular and extracellular matrix structural properties on chondrocyte mechanics.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2018Article
- Effects of Inflammation on Multiscale Biomechanical Properties of Cartilaginous Cells and Tissues.ACS biomaterials science & engineering · 2017Review
- Multiscale cartilage biomechanics: technical challenges in realizing a high-throughput modelling and simulation workflow.Interface focus · 2015Article
- The structure and function of the pericellular matrix of articular cartilage.Matrix biology : journal of the International Society for Matrix Biology · 2014Review
- High resistance of the mechanical properties of the chondrocyte pericellular matrix to proteoglycan digestion by chondroitinase, aggrecanase, or hyaluronidase.Journal of the mechanical behavior of biomedical materials · 2014Article
- A biphasic multiscale study of the mechanical microenvironment of chondrocytes within articular cartilage under unconfined compression.Journal of biomechanics · 2014Article
- Micromechanical mapping of early osteoarthritic changes in the pericellular matrix of human articular cartilage.Osteoarthritis and cartilage · 2013Article
- Evaluation of a post-processing approach for multiscale analysis of biphasic mechanics of chondrocytes.Computer methods in biomechanics and biomedical engineering · 2013Article
- Depth-dependent anisotropy of the micromechanical properties of the extracellular and pericellular matrices of articular cartilage evaluated via atomic force microscopy.Journal of biomechanics · 2013Article
- A review of the combination of experimental measurements and fibril-reinforced modeling for investigation of articular cartilage and chondrocyte response to loading.Computational and mathematical methods in medicine · 2013Review
- Superficial collagen fibril modulus and pericellular fixed charge density modulate chondrocyte volumetric behaviour in early osteoarthritis.Computational and mathematical methods in medicine · 2013Article
- Multiscale mechanics of articular cartilage: potentials and challenges of coupling musculoskeletal, joint, and microscale computational models.Annals of biomedical engineering · 2012Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim was to assess the role of the composition changes in the pericellular matrix (PCM) for the chondrocyte deformation. For that, a three-dimensional finite element model with depth-dependent collagen density, fluid fraction, fixed charge density and collagen architecture, including parallel planes representing the split-lines, was created to model the extracellular matrix (ECM). The PCM was constructed similarly as the ECM, but the collagen fibrils were oriented parallel to the chondrocyte surfaces. The chondrocytes were modelled as poroelastic with swelling properties. Deformation behaviour of the cells was studied under 15% static compression. Due to the depth-dependent structure and composition of cartilage, axial cell strains were highly depth-dependent. An increase in the collagen content and fluid fraction in the PCMs increased the lateral cell strains, while an increase in the fixed charge density induced an inverse behaviour. Axial cell strains were only slightly affected by the changes in PCM composition. We conclude that the PCM composition plays a significant role in the deformation behaviour of chondrocytes, possibly modulating cartilage development, adaptation and degeneration. The development of cartilage repair materials could benefit from this information.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.