ArticlePediatric nephrology (Berlin, Germany)2010
Kidney growth curves in healthy children from the third trimester of pregnancy until the age of two years. The Generation R Study.
Article in Pediatric nephrology (Berlin, Germany), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Fetal Physiologically Based Pharmacokinetic Models: Systems Information on the Growth and Composition of Fetal Organs.Clinical pharmacokinetics · 2019Pooled it
- Maternal and fetal determinants on kidney size in early childhood: insights from a New York City cohort.BMC nephrology · 2026Article
- The NICHD Fetal 3D Study: A Pregnancy Cohort Study of Fetal Body Composition and Volumes.American journal of epidemiology · 2024Article
- Sexual Dimorphism of Corticosteroid Signaling during Kidney Development.International journal of molecular sciences · 2021Review
- Age-Related Changes in Pediatric Physiology: Quantitative Analysis of Organ Weights and Blood Flows : Age-Related Changes in Pediatric Physiology.The AAPS journal · 2021Article
- The old becomes new: advances in imaging techniques to assess nephron mass in children.Pediatric nephrology (Berlin, Germany) · 2021Review
- Renal Hypoplasia, From Grossly Insufficient to Not Quite Enough: Consideration for Expanded Concepts Based Upon the Author's Perspective With Historical Review.Advances in anatomic pathology · 2020Review
- Maternal and Fetal Folate, Vitamin BAmerican journal of kidney diseases : the official journal of the National Kidney Foundation · 2017Observational
- Fetal first trimester growth is not associated with kidney outcomes in childhood.Pediatric nephrology (Berlin, Germany) · 2017Article
- Are low birth weight neonates at risk for suboptimal renal growth and function during infancy?BMC nephrology · 2016Article
- Influence of common genetic variants on childhood kidney outcomes.Pediatric research · 2016Article
- Vitamin D status during fetal life and childhood kidney outcomes.European journal of clinical nutrition · 2016Article
- Protein intake in infancy and kidney size and function at the age of 6 years: The Generation R Study.Pediatric nephrology (Berlin, Germany) · 2015Article
- First-trimester maternal protein intake and childhood kidney outcomes: the Generation R Study.The American journal of clinical nutrition · 2015Article
- Childhood kidney outcomes in relation to fetal blood flow and kidney size.Journal of the American Society of Nephrology : JASN · 2014Article
- Fetal and infant growth patterns and kidney function at school age.Journal of the American Society of Nephrology : JASN · 2014Article
- Kidney size and function in a multi-ethnic population-based cohort of school-age children.Pediatric nephrology (Berlin, Germany) · 2014Article
- Maternal smoking during pregnancy and kidney volume in the offspring: the Generation R Study.Pediatric nephrology (Berlin, Germany) · 2011Article
- The Generation R Study: design and cohort update 2010.European journal of epidemiology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Information about growth of kidney structures in early life is limited. In a population-based prospective cohort study, from foetal life onwards, we constructed reference curves for kidney growth from the third trimester of pregnancy until early childhood, using data from 1,158 healthy children. Kidney size, defined as length, width, depth and volume, was measured in the third trimester of pregnancy and at the postnatal ages of 6 months and 24 months. Analyses were based on more than 2,500 kidney measurements. In the third trimester of pregnancy and at 6 months of age all kidney measurements were larger in boys than in girls. At 24 months of age, these gender differences were only significant for left kidney structures and right kidney length. Both groups showed trends towards smaller left kidney measurements than right kidney measurements at all ages. Gender-specific reference curves based on post-conceptional and postnatal ages were constructed for left and right kidney length, width, depth and volume. We concluded that kidney size is influenced by age and gender. Left kidney size tended to be smaller than right kidney size, except for kidney length. The reference curves can be used for assessing kidney structures by ultrasound in foetal life and early childhood.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.