ArticleJournal of cancer research and clinical oncology2010
Analysis of the expression of hyaluronan in intraductal and invasive carcinomas of the breast.
Article in Journal of cancer research and clinical oncology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- Article
- Article
- Hyaluronic Acid Present in the Tumor Microenvironment Can Negate the Pro-apototic Effect of a Recombinant Fragment of Human Surfactant Protein D on Breast Cancer Cells.Frontiers in immunology · 2020Article
- Virtual screening-driven repositioning of etoposide as CD44 antagonist in breast cancer cells.Oncotarget · 2016Article
- Hyaluronan, Inflammation, and Breast Cancer Progression.Frontiers in immunology · 2015Review
- Cellular heterogeneity profiling by hyaluronan probes reveals an invasive but slow-growing breast tumor subset.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Development and validation of H11B2C2 monoclonal antibody-reactive hyaluronic acid binding protein: overexpression of HABP during human tumor progression.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Article
- A structural analysis of glycosaminoglycans from lethal and nonlethal breast cancer tissues: toward a novel class of theragnostics for personalized medicine in oncology?Omics : a journal of integrative biology · 2012Article
- Hyaluronan synthase 2 (HAS2) promotes breast cancer cell invasion by suppression of tissue metalloproteinase inhibitor 1 (TIMP-1).The Journal of biological chemistry · 2011Article
- Fluorescent liposomes for differential interactions with glycosaminoglycans.Analytical chemistry · 2011Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo evaluate hyaluronan expression at different stages of tumoral progression in primary breast cancer.
methodsHyaluronan expression was evaluated by histochemical techniques in 42 cases of pure DCIS, in 15 cases of DCIS with a microinvasive component, and in 32 cases of invasive ductal carcinoma of the breast. Staining results were evaluated by calculating the percentage of stained areas by means of a specific software program.
resultsOur results show higher values of hyaluronan expression in invasive breast carcinomas [median of percentage of stained areas 41.1 (range 8-69.2)] and in DCIS with a microinvasive component [48.6 (16.8-62.8)] than in pure DCIS [14.5 (1-44.4)] (p < 0.001, for both).
conclusionsOur study indicates a proportionally higher area of hyaluronan expression in DCIS with a microinvasive component than in pure DCIS, suggesting a key role of this glycosaminoglycan in the early invasive phase of breast carcinomas. Thus, hyaluronan could play an important function in determining the migratory phenotype of cancer cells. Larger size tumors appear to demonstrate an intricate balance between hyaluronan synthesis and degradation, thus conditioning intratumoral heterogeneity in the hyaluronan metabolism.
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