ArticleThe open psychiatry journal2009
Glutamate Neurotransmission in Psychotic Disorders and Substance Abuse.
Article in The open psychiatry journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 8 citations in OpenAlex.
- Reduced Levels and Disrupted Biosynthesis Pathways of Plasma Free Fatty Acids in First-Episode Antipsychotic-Naïve Schizophrenia Patients.Frontiers in neuroscience · 2020Article
- Potential drug targets and treatment of schizophrenia.Inflammopharmacology · 2017Review
- Adolescent Traumatic Brain Injury Induces Chronic Mesolimbic Neuroinflammation with Concurrent Enhancement in the Rewarding Effects of Cocaine in Mice during Adulthood.Journal of neurotrauma · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Psychotropic substance abuse and addiction are very prevalent among individuals with major psychiatric disorders world wide. However, this significant association is poorly explained. The dopaminergic circuits have been implemented in addiction as well as in schizophrenia. Recently the important role of glutamatergic neurotransmission has gained attention and current theoretical models of psychosis and substance abuse support the role of interactions between glutamate and other neurotransmitters in the patho-physiology of both disorders. However, the identification of the underlying genetic risk factors remains challenging and not a single genomic variant has been identified with certainty, possibly due to important limitations of the methods used. Clinical trials with glutamatergic neurotransmission modulators, even though still controversial, support the role of glutamate in psychosis and justify further research.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.