ArticlePloS one2009
Determinants of the relationship between cytokine production in pregnant women and their infants.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 33 citations in OpenAlex.
- Socioeconomic disadvantage, gestational immune activity, and neurodevelopment in early childhood.Proceedings of the National Academy of Sciences of the United States of America · 2017Trial
- A longitudinal study of BCG vaccination in early childhood: the development of innate and adaptive immune responses.PloS one · 2010Trial
- Decoupling of maternal and neonatal inflammatory levels at the maternal-fetal interface: evidence from a population-based proteomic study.Frontiers in immunology · 2026Article
- Differences in mid-gestational and early postnatal neonatal cytokines and chemokines are associated with patterns of maternal autoantibodies in the context of autism.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Maternal Inflammatory Biomarkers during Pregnancy and Early Life Neurodevelopment in Offspring: Results from the VDAART Study.International journal of molecular sciences · 2022Article
- Interplay of Environmental, Individual and Genetic Factors in Rheumatoid Arthritis Provocation.International journal of molecular sciences · 2022Review
- Maternal immune activation and dietary soy isoflavone supplementation influence pig immune function but not muscle fiber formation.Journal of animal science · 2022Article
- Associations of IL13 gene polymorphisms and immune factors with Schistosoma haematobium infection in schoolchildren in four schistosomiasis-endemic communities in Ghana.PLoS neglected tropical diseases · 2021Article
- Associations between maternal cytokine levels during gestation and measures of child cognitive abilities and executive functioning.Brain, behavior, and immunity · 2018Article
- Maternal Smoking and Newborn Cytokine and Immunoglobulin Levels.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2017Article
- Maternal and child cytokine relationship in early life is not altered by cytokine gene polymorphisms.Genes and immunity · 2016Article
- Maternal Helminth Infection Is Associated With Higher Infant Immunoglobulin A Titers to Antigen in Orally Administered Vaccines.The Journal of infectious diseases · 2016Article
- Epigenetics of inflammation, maternal infection, and nutrition.The Journal of nutrition · 2015Review
- A cross sectional analysis of behaviors related to operating gas stoves and pneumonia in U.S. children under the age of 5.BMC public health · 2015Article
- A new approach to oxidative stress and inflammatory signaling during labour in healthy mothers and neonates.Oxidative medicine and cellular longevity · 2015Article
- Fatty acids modulate cytokine and chemokine secretion of stimulated human whole blood cultures in diabetes.Clinical and experimental immunology · 2013Article
- Serum IL-12 is increased in Mexican obese subjects and associated with low-grade inflammation and obesity-related parameters.Mediators of inflammation · 2013Article
- The development of TH2 responses from infancy to 4 years of age and atopic sensitization in areas endemic for helminth infections.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2013Article
- Variation between Populations in the Innate Immune Response to Vaccine Adjuvants.Frontiers in immunology · 2013Article
- Child intellectual development in relation to cytokine levels in umbilical cord blood.American journal of epidemiology · 2012Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exposure to environmental factors during fetal life and infancy is thought to play an important role in the early development of innate and adaptive immunity. The immunological relationship between mother and infant and the effect that environmental exposures have during pregnancy and early childhood have not been studied extensively. Here the production of cytokines was measured in 146 pairs of mothers and their 2- month-old infants. The effect of place of residence, socio-economic variables, parasitic infections as well as maternal and child characteristics on measured cytokine production was determined. Mothers producing high levels of IL-10, IFN-gamma and IL-5 were more likely to have infants who also produced high levels of these cytokines either spontaneously (OR 2.6(95%CI 1.2-5.4), OR 2.9(CI 1.3-6.6), OR 11.2(CI 4.6-27.2), respectively) or in response to PHA (IL-10: OR 3.0(CI 1.4-6.6), IFN-gamma: OR 2.0(CI 1.0-4.2), respectively) even after adjustment for potential confounding variables. This was not the case for TNF-alpha. In response to LPS, place of residence was a strong determinant of infant IL-10 (OR 0.2(CI 0.1-0.9)) and TNF-alpha (OR 0.3(CI 0.1-0.9)) production. Maternal protozoan infections was independently associated with reduced infant IL10 in response to PHA and to LPS as well as reduced TNF-alpha and IFN-gamma in response to PHA. These results indicate strong relationship between maternal and infant's cellular immune responses even after taking into account many environmental influences that could affect infant's response directly or indirectly through uterine microenvironment. However, place of residence and intestinal infections may still directly affect the immune responses of the infant. Taken together, the study provides evidence for imprinted cytokine responses of an infant which may have implications for their reaction to incoming antigens, warranting further investigation into the role that genetics or epigenetics play in shaping the cytokine response by an infant to self or external antigens.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.