Evidence map›Paper›PMID 19898237›Full record

ReviewCurrent opinion in organ transplantation2010

Antihuman leukocyte antigen antibody-induced autoimmunity: role in chronic rejection.

Dilip S Nath, Haseeb Illias Basha, Thalachallour Mohanakumar

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in organ transplantation, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
9.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 71 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Autoantibodies in lung transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2020
    Review
  7. Review
  8. Exosomes expressing the self-antigens myosin and vimentin play an important role in syngeneic cardiac transplant rejection induced by antibodies to cardiac myosin.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2018
    Article
  9. Article
  10. Article
  11. Article
  12. Cardiac allograft vasculopathy: a donor or recipient induced pathology?Journal of cardiovascular translational research · 2015
    Review
  13. Article
  14. Article
  15. Article
  16. Mechanisms of chronic cardiac allograft rejection.Texas Heart Institute journal · 2013
    Review
  17. Review
  18. T regulatory cells play a significant role in modulating MHC class I antibody-induced obliterative airway disease.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2012
    Article
  19. Review
  20. The costimulatory immunogen LPS induces the B-Cell clones that infiltrate transplanted human kidneys.Proceedings of the National Academy of Sciences of the United States of America · 2012
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Dilip S NathDivision of Cardiothoracic Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA.
Haseeb Illias Basha
Thalachallour Mohanakumar
University Surgical Associates · US

Funding

IMMUNE MECHANISMS OF REJECTION IN HUMAN LUNG ALLOGRAFTSR01HL056643 · NHLBI · WASHINGTON UNIVERSITY · PI MOHANAKUMAR, THALACHALLOUR · 1996 to 2015
$6.5M
BASIC SCIENCE RESEARCH TRAINING: CARDIOPULMONARY SURGERYT32HL007776 · NHLBI · WASHINGTON UNIVERSITY · PI DAMIANO, RALPH J · 1994 to 2020
$4.6M
ALLOANTIBODIES TO MHC INDUCES AUTOIMMUNITY AND OBLITERATIVE AIRWAY DISEASE (OAD)R01HL092514 · NHLBI · WASHINGTON UNIVERSITY · PI MOHANAKUMAR, THALACHALLOUR · 2009 to 2018
$3.0M
PATHOGENESIS OF POST-TRANSPLANT BRONCHIOLITIS OBLITERANSR01HL066452 · NHLBI · WASHINGTON UNIVERSITY · PI MOHANAKUMAR, THALACHALLOUR · 2001 to 2004
$1.2M
NHLBI NIH HHS HL092514NHLBI NIH HHS HL56643NHLBI NIH HHS R01 HL056643NHLBI NIH HHS R01 HL066452NHLBI NIH HHS R01 HL092514NHLBI NIH HHS T32 HL007776NHLBI NIH HHS T32 HL07776
6 · The paper itself

Abstract

purpose of reviewWe provide evidence for the role of de-novo development of immune responses to self-antigens in the posttransplant period and its possible induction by alloimmunity in the pathogenesis of chronic rejection following lung, heart and kidney transplantation. The present review details recent findings for the two distinct yet interdependent immune processes in the immunopathogenesis of chronic rejection. RECENT

findingsThe contribution of both humoral and cell-mediated alloimmune responses against mismatched donor histocompatibility antigens (HLA) in the pathogenesis of chronic rejection is well established. Recent studies have focused on development of immune responses to self-antigens during the posttransplant period and its correlation with chronic rejection. These self-antigens include myosin and vimentin in cardiac, K-alpha-1-tubulin and collagen-V in lung and angiotensin II type 1 receptor, collagen-IV and VI in kidney transplants. During the posttransplant period, the development of immune responses to self-antigens is facilitated by induction of a distinct subset of autoreactive T-helper cells referred to as Th17 cells. SUMMARY: Following organ transplantation, tissue injury and remodeling inflicted by antibodies (Abs) to HLA antigens is conducive to develop autoimmunity. Abs to HLA and self-antigens are detectable in the serum of transplant recipients who develop chronic rejection. Anti-HLA Abs are often present transiently but precede the development of Abs to self-antigens.

Indexed as

AutoimmunityGraft SurvivalTransplantation ToleranceAnimalsAutoantibodiesAutoantigensChronic DiseaseGraft RejectionHLA AntigensHumansImmunity, CellularImmunity, HumoralIsoantibodiesOrgan TransplantationTreatment OutcomeAutoantibodiesAutoantigensHLA AntigensIsoantibodies

Identifiers

PMID19898237
PMCPMC2806932
OpenAlexW2024123574

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.