ArticleReproductive sciences (Thousand Oaks, Calif.)2010
Differential effects of clinical doses of antenatal betamethasone on nephron endowment and glomerular filtration rate in adult sheep.
Article in Reproductive sciences (Thousand Oaks, Calif.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- The proportions of term or late preterm births after exposure to early antenatal corticosteroids, and outcomes: systematic review and meta-analysis of 1.6 million infants.BMJ (Clinical research ed.) · 2023Pooled it
- Evaluation of Long-term Outcomes Associated With Preterm Exposure to Antenatal Corticosteroids: A Systematic Review and Meta-analysis.JAMA pediatrics · 2022Pooled it
- Maternal dexamethasone exposure does not affect glucose tolerance but alters renal haemodynamics in FEndocrinology, diabetes & metabolism · 2023Article
- Developmental toxicity and programming alterations of multiple organs in offspring induced by medication during pregnancy.Acta pharmaceutica Sinica. B · 2023Review
- Antenatal Programming of Hypertension: Paradigms, Paradoxes, and How We Move Forward.Current hypertension reports · 2022Review
- Comparison of Blood Pressure and Kidney Markers between Adolescent Former Preterm Infants and Term Controls.Children (Basel, Switzerland) · 2020Article
- Fetal Growth Restriction and Hypertension in the Offspring: Mechanistic Links and Therapeutic Directions.The Journal of pediatrics · 2020Review
- Kidney-Detrimental Factors and Estimated Glomerular Filtration Rate in Preterm Newborns: The Role of Nutrition.Nutrients · 2020Article
- Fetal programming and the angiotensin-(1-7) axis: a review of the experimental and clinical data.Clinical science (London, England : 1979) · 2019Review
- Preterm birth and ventilation decrease surface density of glomerular capillaries in lambs, regardless of postnatal respiratory support mode.Pediatric research · 2017Article
- Sex-dependent effects of antenatal glucocorticoids on insulin sensitivity in adult sheep: role of the adipose tissue renin angiotensin system.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- Nephron number, hypertension, and CKD: physiological and genetic insight from humans and animal models.Physiological genomics · 2017Review
- Sex-specific effect of antenatal betamethasone exposure on renal oxidative stress induced by angiotensins in adult sheep.American journal of physiology. Renal physiology · 2014Article
- Antenatal betamethasone exposure alters renal responses to angiotensin-(1-7) in uninephrectomized adult male sheep.Journal of the renin-angiotensin-aldosterone system : JRAAS · 2013Article
- Antenatal betamethasone exposure is associated with lower ANG-(1-7) and increased ACE in the CSF of adult sheep.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Article
- Fetal betamethasone exposure attenuates angiotensin-(1-7)-Mas receptor expression in the dorsal medulla of adult sheep.Peptides · 2013Article
- Antenatal betamethasone has a sex-dependent effect on the in vivo response to endothelin in adult sheep.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Article
- Article
- Renal function, renal volume, and blood pressure in infants with antecedent of antenatal steroids.Pediatric nephrology (Berlin, Germany) · 2011Article
- Exaggerated sympathetic mediated responses to behavioral or pharmacological challenges following antenatal betamethasone exposure.American journal of physiology. Endocrinology and metabolism · 2011Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Antenatal steroid administration is associated with alterations in fetal kidney development and hypertension. However, a causal relationship between nephron deficit and hypertension has not been established. In this study, we measured nephron number, renal function, and blood pressure in sheep exposed antenataly to betamethasone. Pregnant sheep were given 2 betamethasone doses (0.17 mg/kg) or vehicle at 80 and 81 days gestational age and allowed to deliver at term. Data were obtained from a fetal cohort and 2 adult cohorts and were analyzed by analysis of variance (ANOVA) and/or 2 sample t test. Antenatal betamethasone induced a 26% reduction in the number of nephrons in both males and females in the absence of intrauterine growth restriction and/or prematurity. Adult males presented a reduction in glomerular filtration rate (GFR; 132 +/- 12.7 vs 114 +/- 7.0 mL/min, P < .05). Betamethasone administration was also associated with an increase in arterial blood pressure of similar magnitude in male (mean arterial pressure [MAP] in mm Hg; 98 +/- 2.7 vs 105 +/- 2.4) and female (96 +/- 1.9 vs 105 +/- 2.4) adult sheep and the increase in blood pressure preceded the decrease in GFR in the males. Furthermore, we found no significant association between the magnitude of the decrease in nephron number and the magnitude of the increase in arterial blood pressure. Our data thus support the conclusion that exposure to glucocorticoids at a time of rapid kidney growth is associated with an elevation in blood pressure that does not appear related solely to the reduction in nephron number.
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