ArticleGenetics2010
Functional copies of the Mst77F gene on the Y chromosome of Drosophila melanogaster.
Article in Genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analysis reveals that genes regulated by the Y chromosome in Drosophila melanogaster are preferentially localized to repressive chromatin.Genome biology and evolution · 2013Pooled it
- Male sterility in Drosophila mojavensis × D. arizonae hybrids is not caused by gene movements in the Y chromosome.Evolution; international journal of organic evolution · 2025Article
- Running the gauntlet: challenges to genome integrity in spermiogenesis.Nucleus (Austin, Tex.) · 2024Review
- Derepression of Y-linked multicopy protamine-like genes interferes with sperm nuclear compaction inProceedings of the National Academy of Sciences of the United States of America · 2023Article
- piRNA-mediated gene regulation and adaptation to sex-specific transposon expression inGenes & development · 2021Article
- The Role of Y Chromosome Genes in Male Fertility inGenetics · 2020Article
- Dissecting Fertility Functions ofGenetics · 2020Article
- Article
- Convergent evolution of Y chromosome gene content in flies.Nature communications · 2017Article
- The Drosophila chromosomal protein Mst77F is processed to generate an essential component of mature sperm chromatin.Open biology · 2016Article
- Tandem Duplication Events in the Expansion of the Small Heat Shock Protein Gene Family in Solanum lycopersicum (cv. Heinz 1706).G3 (Bethesda, Md.) · 2016Article
- The intimate genetics of Drosophila fertilization.Open biology · 2015Review
- Long-Read Single Molecule Sequencing to Resolve Tandem Gene Copies: The Mst77Y Region on the Drosophila melanogaster Y Chromosome.G3 (Bethesda, Md.) · 2015Article
- The Release 6 reference sequence of the Drosophila melanogaster genome.Genome research · 2015Article
- Drosophila protamine-like Mst35Ba and Mst35Bb are required for proper sperm nuclear morphology but are dispensable for male fertility.G3 (Bethesda, Md.) · 2014Article
- How do y-chromosomes modulate genome-wide epigenetic States: genome folding, chromatin sinks, and gene expression.Journal of genomics · 2014Review
- Efficient identification of Y chromosome sequences in the human and Drosophila genomes.Genome research · 2013Article
- Article
- Three levels of regulation lead to protamine and Mst77F expression in Drosophila.Developmental biology · 2013Article
- Surprising differences in the variability of Y chromosomes in African and cosmopolitan populations of Drosophila melanogaster.Genetics · 2013Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The Y chromosome of Drosophila melanogaster has <20 protein-coding genes. These genes originated from the duplication of autosomal genes and have male-related functions. In 1993, Russell and Kaiser found three Y-linked pseudogenes of the Mst77F gene, which is a testis-expressed autosomal gene that is essential for male fertility. We did a thorough search using experimental and computational methods and found 18 Y-linked copies of this gene (named Mst77Y-1-Mst77Y-18). Ten Mst77Y genes encode defective proteins and the other eight are potentially functional. These eight genes produce approximately 20% of the functional Mst77F-like mRNA, and molecular evolutionary analysis shows that they evolved under purifying selection. Hence several Mst77Y genes have all the features of functional genes. Mst77Y genes are present only in D. melanogaster, and phylogenetic analysis confirmed that the duplication is a recent event. The identification of functional Mst77Y genes reinforces the previous finding that gene gains play a prominent role in the evolution of the Drosophila Y chromosome.
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