ArticleGenetics2010
Recurrent selection on the Winters sex-ratio genes in Drosophila simulans.
Article in Genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Signatures of sex ratio distortion in humans.bioRxiv : the preprint server for biology · 2026Article
- The evolutionary genomics of meiotic drive.Molecular biology and evolution · 2026Article
- Essential and recurrent roles for hairpin RNAs in silencing de novo sex chromosome conflict in Drosophila simulans.PLoS biology · 2023Article
- The fate of a suppressed X-linked meiotic driver: experimental evolution in Drosophila simulans.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2022Article
- Gene drives gaining speed.Nature reviews. Genetics · 2022Review
- Rapid evolutionary dynamics of an expanding family of meiotic drive factors and their hpRNA suppressors.Nature ecology & evolution · 2021Article
- Satellite DNA-mediated diversification of a sex-ratio meiotic drive gene family in Drosophila.Nature ecology & evolution · 2021Article
- Resistance to natural and synthetic gene drive systems.Journal of evolutionary biology · 2020Review
- Meiotic drive mechanisms: lessons fromProceedings. Biological sciences · 2019Article
- Meiotic drive reduces egg-to-adult viability in stalk-eyed flies.Proceedings. Biological sciences · 2019Article
- Article
- A fast-evolving X-linked duplicate of importin-α2 is overexpressed in sex-ratio drive in Drosophila neotestacea.Molecular ecology · 2018Article
- Unexpected patterns of segregation distortion at a selfish supergene in the fire ant Solenopsis invicta.BMC genetics · 2018Article
- The hpRNA/RNAi Pathway Is Essential to Resolve Intragenomic Conflict in the Drosophila Male Germline.Developmental cell · 2018Article
- Sequence and Structural Diversity of Mouse Y Chromosomes.Molecular biology and evolution · 2017Article
- Contrasting patterns of X-chromosome divergence underlie multiple sex-ratio polymorphisms in stalk-eyed flies.Journal of evolutionary biology · 2017Article
- The Red Queen and King in finite populations.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Occasional recombination of a selfish X-chromosome may permit its persistence at high frequencies in the wild.Journal of evolutionary biology · 2016Article
- R2d2 Drives Selfish Sweeps in the House Mouse.Molecular biology and evolution · 2016Article
- Article
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3 authors.
Funding
Abstract
Selfish genes, such as meiotic drive elements, propagate themselves through a population without increasing the fitness of host organisms. X-linked (or Y-linked) meiotic drive elements reduce the transmission of the Y (X) chromosome and skew progeny and population sex ratios, leading to intense conflict among genomic compartments. Drosophila simulans is unusual in having a least three distinct systems of X chromosome meiotic drive. Here, we characterize naturally occurring genetic variation at the Winters sex-ratio driver (Distorter on the X or Dox), its progenitor gene (Mother of Dox or MDox), and its suppressor gene (Not Much Yang or Nmy), which have been previously mapped and characterized. We survey three North American populations as well as 13 globally distributed strains and present molecular polymorphism data at the three loci. We find that all three genes show signatures of selection in North America, judging from levels of polymorphism and skews in the site-frequency spectrum. These signatures likely result from the biased transmission of the driver and selection on the suppressor for the maintenance of equal sex ratios. Coalescent modeling indicates that the timing of selection is more recent than the age of the alleles, suggesting that the driver and suppressor are coevolving under an evolutionary "arms race." None of the Winters sex-ratio genes are fixed in D. simulans, and at all loci we find ancestral alleles, which lack the gene insertions and exhibit high levels of nucleotide polymorphism compared to the derived alleles. In addition, we find several "null" alleles that have mutations on the derived Dox background, which result in loss of drive function. We discuss the possible causes of the maintenance of presence-absence polymorphism in the Winters sex-ratio genes.
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