ArticleGenetics2010
Control of wing size and proportions by Drosophila myc.
Article in Genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- Epithelial cell competition is promoted by signaling from immune cells.Nature communications · 2025Article
- The Drosophila tumor necrosis factor Eiger promotes Myc supercompetition independent of canonical Jun N-terminal kinase signaling.Genetics · 2024Article
- Spt5 interacts genetically with Myc and is limiting for brain tumor growth inLife science alliance · 2024Article
- Regenerative growth is constrained by brain tumor to ensure proper patterning in Drosophila.PLoS genetics · 2023Article
- Spatially Restricted Regulation of Spätzle/Toll Signaling during Cell Competition.Developmental cell · 2018Article
- Mosaic Analysis inGenetics · 2018Review
- Controlling the Master: Chromatin Dynamics at the MYC Promoter Integrate Developmental Signaling.Genes · 2017Review
- Defective Hfp-dependent transcriptional repression of dMYC is fundamental to tissue overgrowth in Drosophila XPB models.Nature communications · 2015Article
- An ancient defense system eliminates unfit cells from developing tissues during cell competition.Science (New York, N.Y.) · 2014Article
- Socializing with MYC: cell competition in development and as a model for premalignant cancer.Cold Spring Harbor perspectives in medicine · 2014Review
- Supercompetitor status of Drosophila Myc cells requires p53 as a fitness sensor to reprogram metabolism and promote viability.Cell metabolism · 2014Article
- CNBP regulates wing development in Drosophila melanogaster by promoting IRES-dependent translation of dMyc.Cell cycle (Georgetown, Tex.) · 2014Article
- The Drosophila ubiquitin-specific protease Puffyeye regulates dMyc-mediated growth.Development (Cambridge, England) · 2013Article
- Myc function in Drosophila.Cold Spring Harbor perspectives in medicine · 2013Review
- Regulation of proliferation, cell competition, and cellular growth by the Drosophila JAK-STAT pathway.JAK-STAT · 2013Review
- Brk regulates wing disc growth in part via repression of Myc expression.EMBO reports · 2013Article
- Genetic systems to investigate regulation of oncogenes and tumour suppressor genes in Drosophila.Cells · 2012Article
- Activated STAT regulates growth and induces competitive interactions independently of Myc, Yorkie, Wingless and ribosome biogenesis.Development (Cambridge, England) · 2012Article
- New frontiers in cell competition.Developmental dynamics : an official publication of the American Association of Anatomists · 2012Review
- Identification of cis-Regulatory Elements in the dmyc Gene of Drosophila Melanogaster.Gene regulation and systems biology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Generation of an organ of appropriate size and shape requires mechanisms that coordinate growth and patterning, but how this is achieved is not understood. Here we examine the role of the growth regulator dMyc in this process during Drosophila wing imaginal disc development. We find that dMyc is expressed in a dynamic pattern that correlates with fate specification of different regions of the wing disc, leading us to hypothesize that dMyc expression in each region directs its growth. Consistent with this view, clonal analysis of growth in each region demonstrated distinct temporal requirements for dMyc that match its expression. Surprisingly, however, experiments in which dMyc expression is manipulated reveal that the endogenous pattern has only a minor influence on wing shape. Indeed, when dMyc function is completely lacking in the wing disc over most of its development, the discs grow slowly and are small in size but appear morphologically normal. Our experiments indicate, therefore, that rather than directly influence differential growth in the wing disc, the pattern of dMyc expression augments growth directed by other regulators. Overall, however, an appropriate level of dMyc expression in the wing disc is necessary for each region to achieve a proportionately correct size.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.