ArticleAmerican journal of physiology. Heart and circulatory physiology2010
Multiple abnormalities of myocardial insulin signaling in a porcine model of diet-induced obesity.
Article in American journal of physiology. Heart and circulatory physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28 citing papers in PubMed, 50 citations in OpenAlex.
- Integrated Myocardial and Plasma Lipidome Across the Human Obesity-Heart Failure Spectrum.Research square · 2026Article
- Cardioprotective Effects of 1-(3,6-Dibromo-carbazol-9-yl)-3-Phenylamino-Propan-2-Ol in Diabetic Hearts via Nicotinamide Phosphoribosyltransferase Activation.The Journal of pharmacology and experimental therapeutics · 2022Article
- Glucose Counteracts Isoprenaline Effects on Ion Channel Functions in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes.Journal of cardiovascular development and disease · 2022Article
- Insulin signaling in the heart.American journal of physiology. Endocrinology and metabolism · 2021Review
- Regulation of hepatic NaMolecular and cellular biochemistry · 2018Article
- Dietary normalization from a fat, fructose and cholesterol-rich diet to chow limits the amount of myocardial collagen in a Göttingen Minipig model of obesity.Nutrition & metabolism · 2018Article
- Changes in cardiac NaMolecular and cellular biochemistry · 2017Article
- Down-regulation of Insulin Receptor Substrate 1 during Hyperglycemia Induces Vascular Smooth Muscle Cell Dedifferentiation.The Journal of biological chemistry · 2017Article
- Long-term feeding of high-fat plus high-fructose diet induces isolated impaired glucose tolerance and skeletal muscle insulin resistance in miniature pigs.Diabetology & metabolic syndrome · 2017Article
- Investigating the Metabolic Syndrome: Contributions of Swine Models.Toxicologic pathology · 2016Review
- Adipose tissue remodeling in a novel domestic porcine model of diet-induced obesity.Obesity (Silver Spring, Md.) · 2015Article
- Use of metformin in diseases of aging.Current diabetes reports · 2014Review
- Cardiac-specific adipose triglyceride lipase overexpression protects from cardiac steatosis and dilated cardiomyopathy following diet-induced obesity.International journal of obesity (2005) · 2014Article
- Increased persistent sodium current due to decreased PI3K signaling contributes to QT prolongation in the diabetic heart.Diabetes · 2013Article
- Obesity and insulin resistance induce early development of diastolic dysfunction in young female mice fed a Western diet.Endocrinology · 2013Article
- Does resveratrol improve insulin signaling in chronically ischemic myocardium?The Journal of surgical research · 2013Article
- Impaired contractile recovery after low-flow myocardial ischemia in a porcine model of metabolic syndrome.American journal of physiology. Heart and circulatory physiology · 2013Article
- Inflammation in response to n3 fatty acids in a porcine obesity model.Comparative medicine · 2012Article
- Abnormal endocrine pancreas function at birth in cystic fibrosis ferrets.The Journal of clinical investigation · 2012Article
- Insulin resistance: metabolic mechanisms and consequences in the heart.Arteriosclerosis, thrombosis, and vascular biology · 2012Review
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8 authors at 1 institution in 1 country.
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Abstract
Heightened cardiovascular risk among patients with systemic insulin resistance is not fully explained by the extent of atherosclerosis. It is unknown whether myocardial insulin resistance accompanies systemic insulin resistance and contributes to increased cardiovascular risk. This study utilized a porcine model of diet-induced obesity to determine if myocardial insulin resistance develops in parallel with systemic insulin resistance and investigated potential mechanisms for such changes. Micropigs (n = 16) were assigned to control (low fat, no added sugars) or intervention (25% wt/wt coconut oil and 20% high-fructose corn syrup) diet for 7 mo. Intervention diet resulted in obesity, hypertension, and dyslipidemia. Systemic insulin resistance was manifest by elevated fasting glucose and insulin, abnormal response to intravenous glucose tolerance testing, and blunted skeletal muscle phosphatidylinositol-3-kinase (PI 3-kinase) activation and protein kinase B (Akt) phosphorylation in response to insulin. In myocardium, insulin-stimulated glucose uptake, PI 3-kinase activation, and Akt phosphorylation were also blunted in the intervention diet group. These findings were explained by increased myocardial content of p85alpha (regulatory subunit of PI 3-kinase), diminished association of PI 3-kinase with insulin receptor substrate (IRS)-1 in response to insulin, and increased serine-307 phosphorylation of IRS-1. Thus, in a porcine model of diet-induced obesity that recapitulates many characteristics of insulin-resistant patients, myocardial insulin resistance develops along with systemic insulin resistance and is associated with multiple abnormalities of insulin signaling.
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