ArticlePlant physiology2010
The Arabidopsis tandem zinc finger protein AtTZF1 traffics between the nucleus and cytoplasmic foci and binds both DNA and RNA.
Article in Plant physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers.
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104 citing papers in PubMed, 202 citations in OpenAlex.
- Sensing and Filtering Environmental Fluctuations: The Case of Biomolecular Condensates in Plants.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- The CCCH-tandem zinc-finger protein OsTZF1 positively regulates basal immunity but suppresses Piz-t-mediated blast resistance in rice.Plant communications · 2026Article
- Plant P-bodies in post-transcriptional control: Composition, dynamics, and context-dependent roles.Plant communications · 2026Review
- Article
- The non-tandem CCCH zinc finger protein AtC3H26 modulates salt stress response and phosphate starvation response through its ribonuclease activity in Arabidopsis.BMC plant biology · 2025Article
- Genome-wide analysis of the CCCH zinc finger gene family in pineapple (Ananas comosus L.) and their involvement in fruit development and translucency.BMC plant biology · 2025Article
- The Regulatory Roles of RNA-Binding Proteins in Plant Salt Stress Response.Plants (Basel, Switzerland) · 2025Review
- Melatonin suppresses ethylene biosynthesis by inhibiting transcription factor MdREM10 during apple fruit ripening.Horticulture research · 2025Article
- Deciphering drought-response in wheat (Frontiers in plant science · 2025Article
- OfWRKY17-OfC3H49 module responding to high ambient temperature delays flowering via inhibitingHorticulture research · 2025Article
- Modulation of stress granule dynamics by phosphorylation and ubiquitination in plants.iScience · 2024Article
- Article
- Exploring the Role of the Processing Body in Plant Abiotic Stress Response.Current issues in molecular biology · 2024Review
- Overexpression of stress granule protein TZF1 enhances salt stress tolerance by targetingFrontiers in plant science · 2024Article
- Heterologous Expression of TwoInternational journal of molecular sciences · 2023Article
- Genome-Wide Identification, Characterization and Expression Analysis of theInternational journal of molecular sciences · 2023Article
- Genome-Wide Identification and Expression Analysis ofInternational journal of molecular sciences · 2023Article
- A LlMYB305-LlC3H18-LlWRKY33 module regulates thermotolerance in lily.Molecular horticulture · 2023Article
- Review
- Genomic Identification of CCCH-Type Zinc Finger Protein Genes Reveals the Role ofInternational journal of molecular sciences · 2023Article
44 more citing papers are in PubMed but not listed here.
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7 authors at 4 institutions in 1 country.
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Abstract
Processing bodies (PBs) are specialized cytoplasmic foci where mRNA turnover and translational repression can take place. Stress granules are related cytoplasmic foci. The CCCH tandem zinc finger proteins (TZFs) play pivotal roles in gene expression, cell fate specification, and various developmental processes. Human TZF binds AU-rich elements at the 3' untranslated region and recruits decapping, deadenylation, and exonucleolytic enzymes to PBs for RNA turnover. Recent genetic studies indicate that plant TZFs are involved in gene regulation and hormone-mediated environmental responses. It is unknown if plant TZFs can bind RNA and be localized to PBs or stress granules. The Arabidopsis (Arabidopsis thaliana) AtTZF1/AtCTH/AtC3H23 was identified as a sugar-sensitive gene in a previous microarray study. It is characterized by a TZF motif that is distinct from the human TZF. Higher plants such as Arabidopsis and rice (Oryza sativa) each have a gene family containing this unique TZF motif. Here, we show that AtTZF1 can traffic between the nucleus and cytoplasmic foci. AtTZF1 colocalizes with markers of PBs, and the morphology of these cytoplasmic foci resembles that of mammalian PBs and stress granules. AtTZF1-associated cytoplasmic foci are dynamic and tissue specific. They can be induced by dark and wound stresses and are preferentially present in actively growing tissues and stomatal precursor cells. Since AtTZF1 can bind both DNA and RNA in vitro, it raises the possibility that AtTZF1 might be involved in DNA and/or RNA regulation.
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