ArticleJournal of the Royal Society, Interface2010
Deformation micromechanisms of collagen fibrils under uniaxial tension.
Article in Journal of the Royal Society, Interface, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed.
- Microstructure-Informed Hyper-Viscoelastic Model Capturing Soft Tissue Tensile Behavior Across Large Deformations.Journal of the mechanics and physics of solids · 2026Article
- Rational assembly of 3D network materials and electronics through tensile buckling.Science advances · 2025Article
- Loss of collagen content is localized near cartilage lesions on the day of injurious loading and intensified on day 12.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- In-silico simulation of nanoindentation on bone using a 2D cohesive finite element model.Journal of the mechanical behavior of biomedical materials · 2024Article
- Collagen fibrils from both positional and energy-storing tendons exhibit increased amounts of denatured collagen when stretched beyond the yield point.Acta biomaterialia · 2023Article
- Anterior cruciate ligament microfatigue damage detected by collagen autofluorescence in situ.Journal of experimental orthopaedics · 2022Article
- Strain rate induced toughening of individual collagen fibrils.Applied physics letters · 2022Article
- Effect of Glycation on Interlamellar Bonding of Arterial Elastin.Experimental mechanics · 2021Article
- A computational study of mechanical properties of collagen-based bio-composites.International biomechanics · 2020Article
- Impact of Uniaxial Stretching on Both Gliding and Traction Areas of Tendon Explants in a Novel Bioreactor.International journal of molecular sciences · 2020Article
- Processing of collagen based biomaterials and the resulting materials properties.Biomedical engineering online · 2019Review
- Fibrillar architecture at three different sites of the bovine superficial digital flexor tendon.The Journal of veterinary medical science · 2018Article
- Collagenous Extracellular Matrix Biomaterials for Tissue Engineering: Lessons from the Common Sea Urchin Tissue.International journal of molecular sciences · 2017Review
- Multiscale Strain as a Predictor of Impact-Induced Fissuring in Articular Cartilage.Journal of biomechanical engineering · 2017Article
- Tension tests on mammalian collagen fibrils.Interface focus · 2016Article
- Modelling of bone fracture and strength at different length scales: a review.Interface focus · 2016Article
- In situ fibril stretch and sliding is location-dependent in mouse supraspinatus tendons.Journal of biomechanics · 2014Article
- Interfibrillar shear stress is the loading mechanism of collagen fibrils in tendon.Acta biomaterialia · 2014Article
- Modelling the mechanics of partially mineralized collagen fibrils, fibres and tissue.Journal of the Royal Society, Interface · 2014Article
- Glycation cross-linking induced mechanical-enzymatic cleavage of microscale tendon fibers.Matrix biology : journal of the International Society for Matrix Biology · 2014Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Collagen, an essential building block of connective tissues, possesses useful mechanical properties due to its hierarchical structure. However, little is known about the mechanical properties of collagen fibril, an intermediate structure between the collagen molecule and connective tissue. Here, we report the results of systematic molecular dynamics simulations to probe the mechanical response of initially unflawed finite size collagen fibrils subjected to uniaxial tension. The observed deformation mechanisms, associated with rupture and sliding of tropocollagen molecules, are strongly influenced by fibril length, width and cross-linking density. Fibrils containing more than approximately 10 molecules along their length and across their width behave as representative volume elements and exhibit brittle fracture. Shorter fibrils experience a more graceful ductile-like failure. An analytical model is constructed and the results of the molecular modelling are used to find curve-fitted expressions for yield stress, yield strain and fracture strain as functions of fibril structural parameters. Our results for the first time elucidate the size dependence of mechanical failure properties of collagen fibrils. The associated molecular deformation mechanisms allow the full power of traditional material and structural engineering theory to be applied to our understanding of the normal and pathological mechanical behaviours of collagenous tissues under load.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.