ArticleAmerican journal of epidemiology2009
Functional variants in the catalase and myeloperoxidase genes, ambient air pollution, and respiratory-related school absences: an example of epistasis in gene-environment interactions.
Article in American journal of epidemiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Myeloperoxidase G463A polymorphism and lung cancer risk in Asians: a pooled analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Pooled it
- Article
- The role of gene-ambient air pollution interactions in paediatric asthma.European respiratory review : an official journal of the European Respiratory Society · 2022Review
- Association with Ambient Air Pollutants and School Absence Due to Sickness in Schoolchildren: A Case-Crossover Study in a Provincial Town of Japan.International journal of environmental research and public health · 2021Article
- Air Pollution, Oxidative Stress, and Diabetes: a Life Course Epidemiologic Perspective.Current diabetes reports · 2019Review
- Association ofFrontiers in endocrinology · 2019Article
- Oxidative Stress-Related Genetic Variants May Modify Associations of Phthalate Exposures with Asthma.International journal of environmental research and public health · 2017Article
- Chronic effects of air pollution on respiratory health in Southern California children: findings from the Southern California Children's Health Study.Journal of thoracic disease · 2015Review
- Environmental effects on immune responses in patients with atopy and asthma.The Journal of allergy and clinical immunology · 2014Review
- Possible molecular mechanisms linking air pollution and asthma in children.BMC pulmonary medicine · 2014Review
- Combustion-derived flame generated ultrafine soot generates reactive oxygen species and activates Nrf2 antioxidants differently in neonatal and adult rat lungs.Particle and fibre toxicology · 2013Article
- Selection of genes for gene-environment interaction studies: a candidate pathway-based strategy using asthma as an example.Environmental health : a global access science source · 2013Article
- Association study of genes associated to asthma in a specific environment, in an asthma familial collection located in a rural area influenced by different industries.International journal of environmental research and public health · 2012Article
- Article
- Joint analysis for integrating two related studies of different data types and different study designs using hierarchical modeling approaches.Human heredity · 2012Article
- Perinatal gene-gene and gene-environment interactions on IgE production and asthma development.Clinical & developmental immunology · 2012Review
- Understanding risk for psychopathology through imaging gene-environment interactions.Trends in cognitive sciences · 2011Review
- Gene-environment interactions in human disease: nuisance or opportunity?Trends in genetics : TIG · 2011Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The individual effect of functional single nucleotide polymorphisms within the catalase and myeloperoxidase genes (CAT and MPO) has been studied in relation to asthma; however, their interrelationship with ambient air pollution exposures has yet to be determined. The authors investigated the interrelationships between variants in CAT and MPO, ambient air pollutants, and acute respiratory illness. Health information, air pollution, and incident respiratory-related school absences were ascertained in January-June 1996 for 1,136 Hispanic and non-Hispanic white US elementary schoolchildren as part of the prospective Children's Health Study. Functional and tagging single nucleotide polymorphisms for the CAT and MPO loci were genotyped. The authors found epistasis between functional polymorphisms in the CAT/MPO loci, which differed by levels of oxidant-stress-producing air pollutants. Risk of respiratory-related school absences was elevated for children with the CAT (G/G) and MPO (G/A or A/A) genes (relative risk = 1.35, 95% confidence interval: 1.03, 1.77; P-interaction = 0.005). The epistatic effect of CAT and MPO variants was most evident in communities exhibiting high ambient ozone levels (P-interaction = 0.03). The association of respiratory-illness absences with functional variants in CAT and MPO that differ by air pollution levels illustrates the need to consider genetic epistasis in assessing gene-environment interactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.