ArticleThe Journal of biological chemistry2010
Integration of a phosphatase cascade with the mitogen-activated protein kinase pathway provides for a novel signal processing function.
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Antioxidants ameliorates glucose/glucose oxidase-induced myocardial damage through mitochondrial and MAPK pathway.3 Biotech · 2025Article
- Quantitative modeling of signaling in aggressive B cell lymphoma unveils conserved core network.PLoS computational biology · 2024Article
- Troponin I modulation of cardiac performance: Plasticity in the survival switch.Archives of biochemistry and biophysics · 2019Review
- Long non-coding RNA Gm2199 rescues liver injury and promotes hepatocyte proliferation through the upregulation of ERK1/2.Cell death & disease · 2018Article
- Sharing of Phosphatases Promotes Response Plasticity in Phosphorylation Cascades.Biophysical journal · 2018Article
- Functional communication between PKC-targeted cardiac troponin I phosphorylation sites.Archives of biochemistry and biophysics · 2017Article
- A Computational Study of the Effects of Syk Activity on B Cell Receptor Signaling Dynamics.Processes (Basel, Switzerland) · 2015Article
- Negative interactions and feedback regulations are required for transient cellular response.Scientific reports · 2014Article
- RETRACTED: Comprehensive logic based analyses of Toll-like receptor 4 signal transduction pathway.PloS one · 2014Article
- Dissecting the roles of tyrosines 490 and 785 of TrkA protein in the induction of downstream protein phosphorylation using chimeric receptors.The Journal of biological chemistry · 2013Article
- Agonist activated PKCβII translocation and modulation of cardiac myocyte contractile function.Scientific reports · 2013Article
- A novel mechanism for ERK-dependent regulation of IL4 transcription during human Th2-cell differentiation.Immunology and cell biology · 2012Article
- Different designs of kinase-phosphatase interactions and phosphatase sequestration shapes the robustness and signal flow in the MAPK cascade.BMC systems biology · 2012Article
- Oscillations in MAPK cascade triggered by two distinct designs of coupled positive and negative feedback loops.BMC research notes · 2012Article
- RETRACTED: Modeling and experimental analyses reveals signaling plasticity in a bi-modular assembly of CD40 receptor activated kinases.PloS one · 2012Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We mathematically modeled the receptor-dependent mitogen-activated protein kinase (MAPK) signaling by incorporating the regulation through cellular phosphatases. Activation induced the alignment of a phosphatase cascade in parallel with the MAPK pathway. A novel regulatory motif was, thus, generated, providing for the combinatorial control of each MAPK intermediate. This ensured a non-linear mode of signal transmission with the output being shaped by the balance between the strength of input signal and the activity gradient along the phosphatase axis. Shifts in this balance yielded modulations in topology of the motif, thereby expanding the repertoire of output responses. Thus, we identify an added dimension to signal processing wherein the output response to an external stimulus is additionally filtered through indicators that define the phenotypic status of the cell.
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