ArticleVirus research2010
beta-Arrestins modulate Adenovirus-vector-induced innate immune responses: differential regulation by beta-arrestin-1 and beta-arrestin-2.
Article in Virus research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 23 citations in OpenAlex.
- β-arrestin2: an emerging player and potential therapeutic target in inflammatory immune diseases.Acta pharmacologica Sinica · 2025Review
- β2-Adrenergic Receptor Expression and Intracellular Signaling in B Cells Are Highly Dynamic during Collagen-Induced Arthritis.Biomedicines · 2022Article
- Adenoviral delivery of an immunomodulatory protein to the tumor microenvironment controls tumor growth.Molecular therapy oncolytics · 2022Article
- β-arrestin 2 attenuates lipopolysaccharide-induced liver injuryWorld journal of gastroenterology · 2018Article
- Down-regulation of β-arrestin2 promotes tumour invasion and indicates poor prognosis of hepatocellular carcinoma.Scientific reports · 2016Article
- Protective Role of β-arrestin2 in Colitis Through Modulation of T-cell Activation.Inflammatory bowel diseases · 2015Article
- Multifaceted role of β-arrestins in inflammation and disease.Genes and immunity · 2015Review
- β-Arrestin 2 negatively regulates Toll-like receptor 4 (TLR4)-triggered inflammatory signaling via targeting p38 MAPK and interleukin 10.The Journal of biological chemistry · 2014Article
- Nonhematopoietic β-Arrestin-1 inhibits inflammation in a murine model of polymicrobial sepsis.The American journal of pathology · 2014Article
- β-Arrestins 1 and 2 are critical regulators of inflammation.Innate immunity · 2014Review
- Arrestins in host-pathogen interactions.Handbook of experimental pharmacology · 2014Article
- Gene dosage-dependent negative regulatory role of β-arrestin-2 in polymicrobial infection-induced inflammation.Infection and immunity · 2013Article
- β-Arrestin-1 deficiency protects mice from experimental colitis.The American journal of pathology · 2013Article
- β-Arrestins in the immune system.Progress in molecular biology and translational science · 2013Review
- β-Arrestins: multifunctional signaling adaptors in type 2 diabetes.Molecular biology reports · 2011Review
- Therapeutic potential of β-arrestin- and G protein-biased agonists.Trends in molecular medicine · 2011Review
- Regulation of lipopolysaccharide-induced inflammatory response and endotoxemia by beta-arrestins.Journal of cellular physiology · 2010Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Adenovirus (Ad)-based vectors have been utilized in human gene transfer clinical trials since 1993. Unfortunately, innate immune responses directed against the Ad capsid and/or its genetic cargo can significantly limit the usage of Ad vectors. Previous studies have demonstrated that several signaling pathways are triggered by Ads, inclusive of TLR-dependent pathways. The G-protein-coupled receptor adaptors beta-arrestin-1 (beta-Arr1) and beta-arrestin-2 (beta-Arr2) are known to have pivotal roles in regulating TLR4 triggered signaling and inflammatory responses. In this study, we examined the role of beta-arrestins in Ad5-vector-induced inflammatory responses. Our studies reveal that both beta-arrestins are capable of modulating Ad5-vector-induced inflammatory responses in vivo and in vitro. Importantly, our studies divulge another level of complexity to these responses, as our results demonstrate beta-Arr1 to be a positive regulator, and beta-Arr2 a negative regulator of Ad5 induced innate immune responses. These data may allow gene therapy biologists to more accurately study the mechanisms underlying Ad5-vector-induced immune responses, and may also direct future efforts to modulate these mechanisms to improve the safety and/or efficacy of this important gene transfer vector.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.