ArticleMechanisms of ageing and development
Significant correlation of species longevity with DNA double strand break recognition but not with telomere length.
Article in Mechanisms of ageing and development. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 72 citations in OpenAlex.
- Article
- Multiplexed, image-based pooled screens in primary cells and tissues with PerturbView.Nature biotechnology · 2025Article
- Structural features of DNA and their potential contribution to blind mole rat (Nannospalax xanthodon) longevity.Biogerontology · 2025Article
- The complex interplay between aging and cancer.Nature aging · 2025Review
- DNA repair and anti-cancer mechanisms in the long-lived bowhead whale.bioRxiv : the preprint server for biology · 2024Article
- Promising Effects of Novel Supplement Formulas in Preventing Skin Aging in 3D Human Keratinocytes.Nutrients · 2024Article
- The need for evolutionary theory in cancer research.European journal of epidemiology · 2023Article
- Xrcc5/Ku80 is required for the repair of DNA damage in fully grown meiotically arrested mammalian oocytes.Cell death & disease · 2023Article
- Tieing together loose ends: telomere instability in cancer and aging.Molecular oncology · 2022Review
- Increased Resection at DSBs in GCells · 2022Article
- Sex-specific aging in animals: Perspective and future directions.Aging cell · 2022Review
- A new approach method for characterizing inter-species toxicodynamic variability.Journal of toxicology and environmental health. Part A · 2021Article
- Balancing DNA repair to prevent ageing and cancer.Experimental cell research · 2021Review
- Copy number analyses of DNA repair genes reveal the role of poly(ADP-ribose) polymerase (PARP) in tree longevity.iScience · 2021Article
- Article
- A pro longevity role for cellular senescence.GeroScience · 2020Article
- Mitochondrial base excision repair positively correlates with longevity in the liver and heart of mammals.GeroScience · 2020Article
- Is the number of DNA repair genes associated with evolution rate and size of genomes?Human genomics · 2020Article
- Nanostructure of Clustered DNA Damage in Leukocytes after In-Solution Irradiation with the Alpha Emitter Ra-223.Cancers · 2019Article
- Hepatitis C Virus NS3 Protein Plays a Dual Role in WRN-Mediated Repair of Nonhomologous End Joining.Journal of virology · 2019Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
The identification of the cellular mechanisms responsible for the wide differences in species lifespan remains one of the major unsolved problems of the biology of aging. We measured the capacity of nuclear protein to recognize DNA double strand breaks (DSBs) and telomere length of skin fibroblasts derived from mammalian species that exhibit wide differences in longevity. Our results indicate DNA DSB recognition increases exponentially with longevity. Further, an analysis of the level of Ku80 protein in human, cow, and mouse suggests that Ku levels vary dramatically between species and these levels are strongly correlated with longevity. In contrast mean telomere length appears to decrease with increasing longevity of the species, although not significantly. These findings suggest that an enhanced ability to bind to DNA ends may be important for longevity. A number of possible roles for increased levels of Ku and DNA-PKcs are discussed.
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