ArticleHuman immunology2010
Effect of human leukocyte antigen homozygosity on rubella vaccine-induced humoral and cell-mediated immune responses.
Article in Human immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- Genetic polymorphisms associated with rubella virus-specific cellular immunity following MMR vaccination.Human genetics · 2014Pooled it
- Human leukocyte antigens and cellular immune responses to anthrax vaccine adsorbed.Infection and immunity · 2013Trial
- The PEGS DREAM Challenge: A Crowdsourcing Approach to Understanding Hypercholesterolemia with Multi- dimensional Genomic and Environmental Data.Research square · 2026Article
- Kgp DNA Vaccine Prevents Experimental Periodontitis.Oral health & preventive dentistry · 2021Article
- Polymorphisms in the Wilms Tumor Gene Are Associated With Interindividual Variations in Rubella Virus-Specific Cellular Immunity After Measles-Mumps-Rubella II Vaccination.The Journal of infectious diseases · 2018Article
- Rubella.Lancet (London, England) · 2015Review
- Polymorphisms in HLA-DPB1 are associated with differences in rubella virus-specific humoral immunity after vaccination.The Journal of infectious diseases · 2015Article
- Methodological aspects of anti-human leukocyte antigen antibody analysis in solid organ transplantation.World journal of transplantation · 2014Review
- Genome-wide SNP associations with rubella-specific cytokine responses in measles-mumps-rubella vaccine recipients.Immunogenetics · 2014Article
- Article
- Vaccinomics and a new paradigm for the development of preventive vaccines against viral infections.Omics : a journal of integrative biology · 2011Review
- Associations between SNPs in candidate immune-relevant genes and rubella antibody levels: a multigenic assessment.BMC immunology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
Human leukocyte antigen (HLA) genes play a critical role in host immunity, including vaccine responses. HLA molecules present antigenic peptides to T cells and provide inhibitory signals to NK cells, and polymorphisms within HLA genes allow binding and presentation of a diverse array of self and foreign peptides. Heterozygosity across HLA alleles has been found to play a positive role in host defense for a variety of infections. Homozygosity within one or more HLA loci may restrict this epitope repertoire and limit T-cell responses to infection or vaccination. Here we report that homozygosity within the HLA DPB1 locus is associated with increased levels of rubella-specific IgG, an effect driven by a common allele DPB1*0401. We also show that homozygosity within different HLA class I and class II loci is correlated with variations (but not necessarily decreases) in interleukin (IL)-2, IL-5, and IL-10 secretion after rubella virus stimulation.
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Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.