ArticleBritish journal of cancer1991
Expression of ecto-5'-nucleotidase (CD73) in normal mammary gland and in breast carcinoma.
Article in British journal of cancer, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- Distinct Capabilities in NAD Metabolism Mediate Resistance to NAMPT Inhibition in Glioblastoma.Cancers · 2024Article
- Unraveling the Intricacies of CD73/Adenosine Signaling: The Pulmonary Immune and Stromal Microenvironment in Lung Cancer.Cancers · 2023Review
- 4-Pyridone-3-carboxamide-1-β-D-ribonucleoside (4PYR)-A Novel Oncometabolite Modulating Cancer-Endothelial Interactions in Breast Cancer Metastasis.International journal of molecular sciences · 2022Article
- The ubiquitin-specific peptidase 22 is a deubiquitinase of CD73 in breast cancer cells.American journal of cancer research · 2022Article
- CD73's Potential as an Immunotherapy Target in Gastrointestinal Cancers.Frontiers in immunology · 2020Review
- Inhibition of the Adenosinergic Pathway in Cancer Rejuvenates Innate and Adaptive Immunity.International journal of molecular sciences · 2019Review
- Review
- Review
- Multifaceted Effects of Extracellular Adenosine Triphosphate and Adenosine in the Tumor-Host Interaction and Therapeutic Perspectives.Frontiers in immunology · 2017Review
- Anti-CD73 in cancer immunotherapy: awakening new opportunities.Trends in cancer · 2016Article
- Loss of CD73-mediated actin polymerization promotes endometrial tumor progression.The Journal of clinical investigation · 2016Article
- CD73s protection of epithelial integrity: Thinking beyond the barrier.Tissue barriers · 2016Article
- Ecto-5'-nucleotidase (CD73) promotes tumor angiogenesis.Clinical & experimental metastasis · 2013Article
- Combining phenotypic and proteomic approaches to identify membrane targets in a 'triple negative' breast cancer cell type.Molecular cancer · 2013Article
- NT5E CpG island methylation is a favourable breast cancer biomarker.British journal of cancer · 2012Article
- Metastasis-related plasma membrane proteins of human breast cancer cells identified by comparative quantitative mass spectrometry.Molecular & cellular proteomics : MCP · 2009Article
- CD73 participates in cellular multiresistance program and protects against TRAIL-induced apoptosis.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- 5'-Nucleotidase: molecular structure and functional aspects.The Biochemical journal · 1992Review
- CD antigens as promising tools for the functional analysis of solid tumours.Virchows Archiv. A, Pathological anatomy and histopathology · 1991Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ecto-5'-nucleotidase (ecto-5'-NT) is a phosphatidylinositol anchored membrane structure recently defined as the lymphocyte differentiation antigen CD73. Using CD73 (1E9.28.1) monoclonal antibody, normal mammary gland and breast carcinoma were immunohistochemically investigated for ecto-5'-NT expression. In normal breast epithelium, CD73 was differentially expressed in lobular, ductal and myoepithelial cells and was most frequently detected in the myoepithelial compartment. The glandular stroma contained fibrocytes, a subset of which was also CD73-positive. Among 102 unselected breast carcinoma primary lesions, only 9 contained CD73-positive tumour cells, whereas in 95 cases, stromal fibroblasts and fibrocytes showed variable degrees of CD73 expression. The extent of stromal CD73 expression correlated positively with the estrogen receptor (ER) status of the tumour (P less than 0.038). We conclude that ecto-5'-NT-expression reflects a still unknown state of activity of normal breast epithelium which is lost in the majority of carcinomas derived therefrom. It may also be indicative of some functional activity of stromal fibroblasts which is significantly enhanced in ER-positive carcinomas.
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