ReviewCurrent opinion in structural biology2009
Elongation by RNA polymerase: a race through roadblocks.
Review in Current opinion in structural biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- Efficient, ultra-high-affinity chromatography in a one-step purification of complex proteins.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Characterization of molecular interactions between Escherichia coli RNA polymerase and topoisomerase I by molecular simulations.FEBS letters · 2016Article
- Differences between cotranscriptional and free riboswitch folding.Nucleic acids research · 2014Article
- NusG-Spt5 proteins-Universal tools for transcription modification and communication.Chemical reviews · 2013Review
- Transformation: the next level of regulation.RNA biology · 2012Article
- Inhibition of Mycobacterium tuberculosis RNA polymerase by binding of a Gre factor homolog to the secondary channel.Journal of bacteriology · 2012Article
- NusA interaction with the α subunit of E. coli RNA polymerase is via the UP element site and releases autoinhibition.Structure (London, England : 1993) · 2011Article
- Evolution of multisubunit RNA polymerases in the three domains of life.Nature reviews. Microbiology · 2011Review
- A transcript cleavage factor of Mycobacterium tuberculosis important for its survival.PloS one · 2011Article
- The nucleotide addition cycle of RNA polymerase is controlled by two molecular hinges in the Bridge Helix domain.BMC biology · 2010Article
- The NusA N-terminal domain is necessary and sufficient for enhancement of transcriptional pausing via interaction with the RNA exit channel of RNA polymerase.Journal of molecular biology · 2010Article
- Promoter melting triggered by bacterial RNA polymerase occurs in three steps.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Transcription is the first and most regulated step of gene expression. RNA polymerase (RNAP) is the heart of the transcription machinery and a major target for numerous regulatory pathways in living cells. The crystal structures of transcription complexes formed by bacterial RNAP in various configurations have provided a number of breakthroughs in understanding basic, universal mechanisms of transcription and have revealed regulatory 'hot spots' in RNAP that serve as targets and anchors for auxiliary transcription factors. In combination with biochemical analyses, these structures allow feasible modeling of the regulatory complexes for which experimental structural data are still missing. The available structural information suggests a number of general mechanistic predictions that provide a reference point and direction for future studies of transcription regulation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.