ArticleAcademic radiology2009
Longitudinal assessment of colonic tumor fate in mice by computed tomography and optical colonoscopy.
Article in Academic radiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 15 citations in OpenAlex.
- High Variability in Cellular Proliferation, Gene Expression, and Cytokine Production in the Nonneoplastic Colonic Epithelium of YoungFrontiers in oncology · 2021Article
- Fisetin and 5-fluorouracil: Effective combination for PIK3CA-mutant colorectal cancer.International journal of cancer · 2019Article
- Heterochromatin Protein 1 Binding Protein 3 Expression as a Candidate Marker of Intrinsic 5-Fluorouracil Resistance.Anticancer research · 2016Article
- Dual optical modality endoscopic imaging of cancer development in the mouse colon.Lasers in surgery and medicine · 2015Article
- A simple, quantitative method using alginate gel to determine rat colonic tumor volume in vivo.Comparative medicine · 2014Article
- Colonoscopy as a tool for evaluating colorectal tumor development in a mouse model.International journal of colorectal disease · 2014Article
- Dynamic tumor growth patterns in a novel murine model of colorectal cancer.Cancer prevention research (Philadelphia, Pa.) · 2014Article
- Multimodal imaging of growth and rapamycin-induced regression of colonic adenomas in apc mutation-dependent mouse.Translational oncology · 2012Article
- The many ways to open the gate to colon cancer.Cell cycle (Georgetown, Tex.) · 2012Article
- Supplementation by vitamin D compounds does not affect colonic tumor development in vitamin D sufficient murine models.Archives of biochemistry and biophysics · 2011Article
- Double-contrast micro-CT colonoscopy in live mice.International journal of colorectal disease · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
RATIONALE AND
objectivesThe purpose of this study was to evaluate the relative merits of micro-computed tomograph colonography (mCTC) and optical colonoscopy (OC) for longitudinal studies of colonic tumors in mice. MATERIALS AND
methodsColonic tumors in mice carrying the Min allele of Apc were followed over several weeks using mCTC and OC. A total of 146 colonic tumors were monitored: 62 in 32 untreated Min mice, 53 in 43 Min mice treated with 5-fluorouracil (5-FU), and 31 in 17 Min mice treated with piroxicam.
resultsColonic tumors in Min mice had three different spontaneous fates: 29 grew, 24 remained static, and 9 regressed. Treating Min mice with 5-FU increased the percentage of regressing tumors from 15% to 58%. The response was dependent in part on the initial size of the tumor. By contrast, treating Min mice with piroxicam did not alter colonic tumor fate.
conclusionsmCTC and OC can be used to determine the spontaneous fates of colonic tumors in mice and to document their individual responses to treatment. The ability to follow individually annotated colonic tumors reduces the number of mice needed for testing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.