ArticleNeuroscience letters2010
Neurochemical, behavioral and architectural changes after chronic inactivation of NMDA receptors in mice.
Article in Neuroscience letters, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
- MK-801 and cognitive functions: Investigating the behavioral effects of a non-competitive NMDA receptor antagonist.Psychopharmacology · 2023Review
- Prostacyclin Promotes Degenerative Pathology in a Model of Alzheimer's Disease.Frontiers in cellular neuroscience · 2022Article
- Placental transfer of NMDAR antibodies causes reversible alterations in mice.Neurology(R) neuroimmunology & neuroinflammation · 2021Article
- Kynurenine Pathway as a New Target of Cognitive Impairment Induced by Lead Toxicity During the Lactation.Scientific reports · 2020Article
- Chronic MK-801 Application in Adolescence and Early Adulthood: A Spatial Working Memory Deficit in Adult Long-Evans Rats But No Changes in the Hippocampal NMDA Receptor Subunits.Frontiers in pharmacology · 2018Article
- Cannabidiol attenuates sensorimotor gating disruption and molecular changes induced by chronic antagonism of NMDA receptors in mice.The international journal of neuropsychopharmacology · 2014Article
- Elevated prostacyclin biosynthesis in mice impacts memory and anxiety-like behavior.Behavioural brain research · 2014Article
- Chronic treatment with DCPCX, an adenosine A(1) antagonist, worsens long-term memory.Neuroscience letters · 2013Article
- Article
- Pharmacological inactivation of the small GTPase Rac1 impairs long-term plasticity in the mouse hippocampus.NeuropharmacologyArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Schizophrenia is a psychotic illness characterized by problems in perception, learning, and memory. Post-mortem clinical data revealed abnormalities in neuronal organization, reduced soma and dendritic tree size. In rodents, reduction of glutamatergic neurotransmission by NMDA receptor antagonists mimics symptoms of schizophrenia. However, the dosage, treatment and species used in previous studies have not been consistent, leading to a lack of correlation between the findings reported in low-dose, long-term treatment models and the results in acute or chronic high dose administration. Thus, the present study investigates whether long-term, low-dose blockade of NMDA receptors with MK-801 in the early postnatal period results in molecular, cellular, morphological and behavioral changes in the mouse, alterations that have been singly described by using different drugs and dosages in either mice or rats. We found that early postnatal administration of 0.1mg/kg MK-801 for 15 days altered protein translation, synapse formation, hippocampus-dependent learning and neuronal development, resembling findings reported in schizophrenia. These results suggest that there are strong parallels between this animal model and schizophrenia, which validates it as an animal model for this condition and lends further strength of the NMDA receptor hypofunction as a useful model for the study of psychosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.