ArticleThe Biochemical journal1991
Changes in the mechanism of Ca2(+) mobilization during the differentiation of BC3H1 muscle cells.
Article in The Biochemical journal, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 43 citations in OpenAlex.
- Trisk 32 regulates IP(3) receptors in rat skeletal myoblasts.Pflugers Archiv : European journal of physiology · 2011Article
- STIM1 as a key regulator for Ca2+ homeostasis in skeletal-muscle development and function.Skeletal muscle · 2011Article
- Effects of the immunosuppressant FK506 on intracellular Ca2+ release and Ca2+ accumulation mechanisms.The Journal of physiology · 2000Article
- Myostatin levels in regenerating rat muscles and in myogenic cell cultures.Journal of muscle research and cell motility · 2000Article
- Differential expression and regulation of ryanodine receptor and myo-inositol 1,4,5-trisphosphate receptor Ca2+ release channels in mammalian tissues and cell lines.The Biochemical journal · 1997Article
- Isoform diversity of the inositol trisphosphate receptor in cell types of mouse origin.The Biochemical journal · 1997Article
- Differentiation of BC3H1 smooth muscle cells changes the bivalent cation selectivity of the capacitative Ca2+ entry pathway.The Biochemical journal · 1996Article
- Different pathways of inositol phosphate metabolism in intact neonatal rat hearts and isolated cardiomyocytes.The Biochemical journal · 1992Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ca2+ sequestration and release in BC3H1 muscle cells is strongly dependent on the stage of differentiation. In proliferating cells, more than 90% of the sequestered Ca2+ was Ins(1,4,5)P3-sensitive and 25% was caffeine-sensitive. In differentiated cells, the Ca2+ accumulation was 5-fold higher and was InsP3-insensitive, but about 60% of the sequestered Ca2+ was caffeine-sensitive. These changes were reversible upon addition of growth stimuli. Similarly, by measuring the intracellular Ca2+ concentration in single intact BC3H1 cells, it was found that the number of histamine-responsive cells decreased and the number of caffeine-responsive cells increased during muscle cell differentiation. These data indicate that the development of the muscle phenotype in BC3H1 myoblasts induces a major rearrangement of the mechanisms for Ca2+ mobilization.
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