Evidence map›Paper›PMID 19895837›Full record

ReviewAdvances in enzyme regulation2010

Targeting signal transduction pathways to eliminate chemotherapeutic drug resistance and cancer stem cells.

James A McCubrey, Stephen L Abrams, Kristin Stadelman, William H Chappell, Michelle Lahair, Richard A Ferland, Linda S Steelman

Abstract readReview
In one paragraph

Review in Advances in enzyme regulation, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Gli1, a potential cancer stem cell marker, is strongly associated with prognosis in prostate cancer.International journal of clinical and experimental pathology · 2018
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. MicroRNAs targeting prostate cancer stem cells.Experimental biology and medicine (Maywood, N.J.) · 2015
    Review
  11. Soy isoflavones and prostate cancer: a review of molecular mechanisms.The Journal of steroid biochemistry and molecular biology · 2014
    Review
  12. Article
  13. Cancer stem cell theory: therapeutic implications for nanomedicine.International journal of nanomedicine · 2013
    Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

James A McCubreyEast Carolina University, Greenville, NC, USA. mccubreyj@ecu.edu
Stephen L Abrams
Kristin Stadelman
William H Chappell
Michelle Lahair
Richard A Ferland
Linda S Steelman

Funding

Ras/Raf &PI3K/Akt Induced Breast Cancer Drug ResistanceR01CA098195 · NCI · EAST CAROLINA UNIVERSITY · PI MC CUBREY, JAMES A · 2003 to 2007
$1.5M
NCI NIH HHS R01 CA098195
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Antineoplastic AgentsBreast NeoplasmsNeoplastic Stem CellsAnimalsCalcium-Calmodulin-Dependent Protein KinasesCell Line, TumorDrug ResistanceEnzyme ActivationFemaleHumansMitogen-Activated Protein KinasesNeoplasm MetastasisPhosphatidylinositol 3-KinasesPTEN PhosphohydrolaseSignal TransductionAntineoplastic AgentsCalcium-Calmodulin-Dependent Protein KinasesMitogen-Activated Protein KinasesPhosphatidylinositol 3-KinasesPTEN Phosphohydrolase

Identifiers

PMID19895837
PMCPMC2862855

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.