Evidence map›Paper›PMID 19895816›Full record

ArticleJournal of molecular biology2010

Molecular evolution of multisubunit RNA polymerases: structural analysis.

William J Lane, Seth A Darst

Abstract read
In one paragraph

Article in Journal of molecular biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers.

0numbers the graph read from it
0cells of the map it votes in
99citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

99 citing papers in PubMed.

  1. Review
  2. The biology of jumbo phages.Nature communications · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. BEAN and HABAS: Polyphyletic insertions in the DNA-directed RNA polymerase.Protein science : a publication of the Protein Society · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Investigation of Multi-SubunitInternational journal of molecular sciences · 2023
    Article

39 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

William J LaneThe Rockefeller University, Box 224, 1230 York Avenue, New York, NY 10065, USA.
Seth A Darst

Funding

Weill Cornell/Rockefeller/Sloan-Kettering MST ProgramT32GM007739 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI HSU, KATHARINE C · 1985 to 2023
$51.1M
E COLI RNA POLYMERASE SUBUNIT--STRUCTURE/FUNCTIONR01GM053759 · NIGMS · ROCKEFELLER UNIVERSITY · PI DARST, SETH A. · 1996 to 2015
$6.9M
X-RAY CRYSTALLOGRAPHIC STUDIES OF TAQ RNA POLYMERASER01GM061898 · NIGMS · ROCKEFELLER UNIVERSITY · PI DARST, SETH A. · 2000 to 2008
$3.3M
NIGMS NIH HHS GM053759NIGMS NIH HHS GM061898NIGMS NIH HHS GM07739NIGMS NIH HHS R01 GM053759NIGMS NIH HHS R01 GM061898NIGMS NIH HHS T32 GM007739
6 · The paper itself

Abstract

Comprehensive multiple sequence alignments of the multisubunit DNA-dependent RNA polymerase (RNAP) large subunits, including the bacterial beta and beta' subunits and their homologs from archaebacterial RNAPs, eukaryotic RNAPs I-III, nuclear-cytoplasmic large double-stranded DNA virus RNAPs, and plant plastid RNAPs, were created [Lane, W. J. and Darst, S. A. (2009). Molecular evolution of multisubunit RNA polymerases: sequence analysis. In press]. The alignments were used to delineate sequence regions shared among all classes of multisubunit RNAPs, defining common, fundamental RNAP features as well as identifying highly conserved positions. Here, we present a systematic, detailed structural analysis of these shared regions and highly conserved positions in terms of the RNAP structure, as well as the RNAP structure/function relationship, when known.

Indexed as

Evolution, MolecularBacterial ProteinsCatalytic DomainConserved SequenceDNA-Directed RNA PolymerasesGenes, BacterialGlycineModels, MolecularPhylogenyProtein MultimerizationProtein Structure, TertiaryProtein SubunitsSequence AlignmentStructural Homology, ProteinThermus thermophilusBacterial ProteinsDNA-Directed RNA PolymerasesGlycineProtein Subunits

Identifiers

PMID19895816
PMCPMC2813324

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.