ArticleBiomacromolecules2009
Kinetics of nanoparticle targeting by dissipative particle dynamics simulations.
Article in Biomacromolecules, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Predictive Design and Analysis of Drug Transport by Multiscale Computational Models Under Uncertainty.Pharmaceutical research · 2023Review
- Development of Janus Particles as Potential Drug Delivery Systems for Diabetes Treatment and Antimicrobial Applications.Pharmaceutics · 2023Review
- Anti-Epcam Aptamer (Syl3c)-Functionalized Liposome for Targeted Delivery Of Doxorubicin: In Vitro And In Vivo Antitumor Studies in Mice Bearing C26 Colon Carcinoma.Nanoscale research letters · 2020Article
- Evolution of Multivalent Nanoparticle Adhesion via Specific Molecular Interactions.Langmuir : the ACS journal of surfaces and colloids · 2016Article
- Modeling Nanoparticle Targeting to a Vascular Surface in Shear Flow Through Diffusive Particle Dynamics.Nanoscale research letters · 2015Article
- Receptor-mediated membrane adhesion of lipid-polymer hybrid (LPH) nanoparticles studied by dissipative particle dynamics simulations.Nanoscale · 2015Article
- Avidity mechanism of dendrimer-folic acid conjugates.Molecular pharmaceutics · 2014Article
- The shape of things to come: importance of design in nanotechnology for drug delivery.Therapeutic delivery · 2012Review
- Modeling particle shape-dependent dynamics in nanomedicine.Journal of nanoscience and nanotechnology · 2011Article
- Nanoparticle design optimization for enhanced targeting: Monte Carlo simulations.Biomacromolecules · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Dissipative particle dynamics simulations are applied to study nanoparticle targeting to a cell surface containing a high concentration of receptors. We found that the normalized number of bound ligands follows an exponential growth function 1 - exp(-t/tau), with the lifetime tau increasing as a function of the binding strength. With increasing binding energy, the shape of the adsorbed nanoparticle becomes ellipsoidal due to a large number of stably bound ligands, most of which are positioned on the nanoparticle periphery. For a low degree of functionalization of homogeneously distributed ligands, the kinetics of nanoparticle attachment slows down due to interference by nonfunctional chains, the overall number of bound ligands at equilibrium decreases, although the stability of ligand attachment increases. Janus-like nanoparticles with functionalized chains positioned on one side of the nanoparticle exhibit more rapid binding to the cell surface with a large equilibrium number of stably bound ligands.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.