ArticleAmerican journal of hypertension2010
Sexual dimorphism in the blood pressure response to angiotensin II in mice after angiotensin-converting enzyme blockade.
Article in American journal of hypertension, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Sex differences in the renin-angiotensin-aldosterone system and its roles in hypertension, cardiovascular, and kidney diseases.Frontiers in cardiovascular medicine · 2023Review
- Angiotensin II and ATInternational journal of molecular sciences · 2022Review
- Sex differences in angiotensin II-induced hypertension and kidney injury: role of AT1a receptors in the proximal tubule of the kidney.Clinical science (London, England : 1979) · 2021Article
- Estrogen-related mechanisms in sex differences of hypertension and target organ damage.Biology of sex differences · 2020Review
- Subfornical organ insulin receptors tonically modulate cardiovascular and metabolic function.Physiological genomics · 2019Article
- Female C57BL/6J mice lacking the circadian clock protein PER1 are protected from nondipping hypertension.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- Sex and gender differences in control of blood pressure.Clinical science (London, England : 1979) · 2013Review
- Endothelin ET(B) receptors contribute to sex differences in blood pressure elevation in angiotensin II hypertensive rats on a high-salt diet.Clinical and experimental pharmacology & physiology · 2013Article
- Sex differences in estrogen receptor promoter expression in the area postrema.Neural regeneration research · 2013Article
- Oxidative stress contributes to sex differences in angiotensin II-mediated hypertension in spontaneously hypertensive rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2012Article
- Angiotensin (1-7) receptor antagonism equalizes angiotensin II-induced hypertension in male and female spontaneously hypertensive rats.Hypertension (Dallas, Tex. : 1979) · 2010Article
- Tumor necrosis factor-alpha antagonist etanercept decreases blood pressure and protects the kidney in a mouse model of systemic lupus erythematosus.Hypertension (Dallas, Tex. : 1979) · 2010Article
- Sex differences in acute ANG II-mediated hemodynamic responses in mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2010Article
- Sex-specific effects of heme oxygenase-2 deficiency on renovascular hypertension.Journal of the American Society of Hypertension : JASHArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe incidence of hypertension and progression of renal disease are greater in men than in women. Data suggest that there is a dimorphic response to angiotensin II (Ang II) in rats, with male rats exhibiting a greater increase in mean arterial pressure (MAP) than females. However, during endogenous renin-angiotensin system (RAS) blockade with angiotensin-converting enzyme (ACE) inhibition, female rats have a greater MAP response to Ang II. We tested whether female mice exhibit a greater MAP response to chronic Ang II during ACE inhibition.
methodsTwenty-week-old male and female C57BL/6J mice (n > or = 6/group), treated with enalapril (40 mg/kg/day in drinking water), were assigned to groups receiving either Ang II (800 ng/kg/min) or saline for 2 weeks. Enalapril treatment began 4 days before and continued throughout the experiment.
resultsMAP was higher in male mice than female mice treated with enalapril and Ang II (male: 144 +/- 3 vs. female: 121 +/- 6 mm Hg, P < 0.05) and was not different between mice treated with enalapril alone (male: 99 +/- 3 vs. female: 100 +/- 3 mm Hg). F2-isoprostanes were not increased by Ang II; however, female mice had significantly higher levels than males. Renal cortical expression of catalase and Cu/Zn-superoxide dismutase (SOD) was not different between experimental groups. Urinary protein was higher in male mice when compared to females, but was not changed after treatment with Ang II in either group.
conclusionsThese data suggest that there are species and sex-specific differences in the mechanism of the blood pressure response to Ang II, even during ACE inhibition.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.