ArticleThe American journal of pathology2009
Fluorescence in situ hybridization markers for prediction of cervical lymph node metastases.
Article in The American journal of pathology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- TBLR1 is a novel prognostic marker and promotes epithelial-mesenchymal transition in cervical cancer.British journal of cancer · 2014Trial
- An Improved Binary Differential Evolution Algorithm to Infer Tumor Phylogenetic Trees.BioMed research international · 2017Article
- Phylogenetic analysis of multiple FISH markers in oral tongue squamous cell carcinoma suggests that a diverse distribution of copy number changes is associated with poor prognosis.International journal of cancer · 2016Article
- Analysis of gene copy number changes in tumor phylogenetics.Algorithms for molecular biology : AMB · 2016Article
- WNT2 Promotes Cervical Carcinoma Metastasis and Induction of Epithelial-Mesenchymal Transition.PloS one · 2016Article
- FISHtrees 3.0: Tumor Phylogenetics Using a Ploidy Probe.PloS one · 2016Article
- Dissecting the Dual Role of AMPK in Cancer: From Experimental to Human Studies.Molecular cancer research : MCR · 2015Review
- Inferring models of multiscale copy number evolution for single-tumor phylogenetics.Bioinformatics (Oxford, England) · 2015Article
- Single-cell genetic analysis reveals insights into clonal development of prostate cancers and indicates loss of PTEN as a marker of poor prognosis.The American journal of pathology · 2014Article
- Algorithms to model single gene, single chromosome, and whole genome copy number changes jointly in tumor phylogenetics.PLoS computational biology · 2014Article
- Phylogenetic analysis of multiprobe fluorescence in situ hybridization data from tumor cell populations.Bioinformatics (Oxford, England) · 2013Article
- Concurrent V(D)J recombination and DNA end instability increase interchromosomal trans-rearrangements in ATM-deficient thymocytes.Nucleic acids research · 2013Article
- Single-cell genetic analysis of ductal carcinoma in situ and invasive breast cancer reveals enormous tumor heterogeneity yet conserved genomic imbalances and gain of MYC during progression.The American journal of pathology · 2012Article
- Inference of tumor phylogenies from genomic assays on heterogeneous samples.Journal of biomedicine & biotechnology · 2012Article
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Authors and funding
11 authors at 7 institutions in 6 countries.
Funding
Abstract
The presence of lymph node metastases is associated with poor prognosis in early stage cervical cancer. As of yet, no molecular markers predicting lymph node metastases have been identified. We examined single genetic markers and a composite marker, comprised of three fluorescence in situ hybridization (FISH) probes targeting the genes LAMP3, PROX1, and PRKAA1, in pretreatment cervical biopsies from 16 lymph node positive cases and 15 lymph node negative controls from women with stage IB and IIA cervical cancer. In addition, we determined clonal patterns by including CCND1 to compare the clonal constitution of primary tumors and associated lymph node metastases. The composite FISH marker allowed for classification of patients into those with and without lymph node metastases with a sensitivity and specificity of 75% and 87%, respectively (P = 0.001). The positive predictive value and negative predictive value were 86% and 76%, respectively. Clonal patterns varied among the tumors. In many cases, changes between the primary tumor and lymph node metastases in the most common clones may indicate that certain clones have a growth advantage for establishing metastases in lymph nodes. We conclude that the composite FISH marker may be useful for determining risk for subsequent development of lymph node metastases in patients with cervical cancer.
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