ArticleScience (New York, N.Y.)2009
A single peptide-MHC complex positively selects a diverse and specific CD8 T cell repertoire.
Article in Science (New York, N.Y.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- Mutation of conserved MHC class I cytoplasmic tyrosine affects CD8+ T cell priming, effector function, and memory response.Frontiers in immunology · 2025Article
- Engineering human pluripotent stem cell lines to evade xenogeneic transplantation barriers.Stem cell reports · 2024Article
- The thymoproteasome in shaping the CD8Current opinion in immunology · 2023Review
- Antigen-guided depletion of anti-HLA antibody-producing cells by HLA-Fc fusion proteins.Blood · 2022Article
- Novel MHC-Independent αβTCRs Specific for CD48, CD102, and CD155 Self-Proteins and Their Selection in the Thymus.Frontiers in immunology · 2020Article
- Stress-testing the relationship between T cell receptor/peptide-MHC affinity and cross-reactivity using peptide velcro.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Targeting Innate-Like T Cells in Tuberculosis.Frontiers in immunology · 2016Review
- Self-recognition drives the preferential accumulation of promiscuous CD4(+) T-cells in aged mice.eLife · 2015Article
- Identification of human T-cell receptors with optimal affinity to cancer antigens using antigen-negative humanized mice.Nature biotechnology · 2015Article
- Oncogene Overdose: Too Much of a Bad Thing for Oncogene-Addicted Cancer Cells.Biomarkers in cancer · 2015Review
- Lung tumor NF-κB signaling promotes T cell-mediated immune surveillance.The Journal of clinical investigation · 2013Article
- Thymic epithelial cells: antigen presenting cells that regulate T cell repertoire and tolerance development.Immunologic research · 2012Review
- Cross-dressed CD8α+/CD103+ dendritic cells prime CD8+ T cells following vaccination.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- How the TCR balances sensitivity and specificity for the recognition of self and pathogens.Nature immunology · 2012Review
- Identification of HLA-A24-restricted CD8(+) cytotoxic T-cell epitopes derived from mammaglobin-A, a human breast cancer-associated antigen.Human immunology · 2012Article
- Tumor-infiltrating myeloid cells induce tumor cell resistance to cytotoxic T cells in mice.The Journal of clinical investigation · 2011Article
- Properties and applications of single-chain major histocompatibility complex class I molecules.Antioxidants & redox signaling · 2011Review
- Opposite effects of endogenous peptide-MHC class I on T cell activity in the presence and absence of CD8.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Design principles of adaptive immune systems.Nature reviews. Immunology · 2011Review
- Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Pathogen recognition by T cells is dependent on their exquisite specificity for self-major histocompatibility complex (MHC) molecules presenting a bound peptide. Although this specificity results from positive and negative selection of developing T cells in the thymus, the relative contribution of these two processes remains controversial. To address the relation between the selecting peptide-MHC complex and the specificity of mature T cells, we generated transgenic mice that express a single peptide-MHC class I complex. We demonstrate that positive selection of CD8 T cells in these mice results in an MHC-specific repertoire. Although selection on a single complex is peptide promiscuous, mature T cells are highly peptide specific. Thus, positive selection imparts MHC and peptide specificity on the peripheral CD8 T cell repertoire.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.