Trial reportOral oncology2010
Development of a gene transfer-based treatment for radiation-induced salivary hypofunction.
Trial report in Oral oncology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 62 citations in OpenAlex.
- Salivary gland tissue chip screening identifies candidate radioprotective drugs.Communications medicine · 2025Article
- Xerostomia: Advances and Challenges in Drug Development.Current drug targets · 2024Article
- In Vivo Transfection of Rat Salivary Glands With Fluorescently Tagged Aquaporin-5 Channel DNA.Cureus · 2022Article
- Diagnosis, Prevention, and Treatment of Radiotherapy-Induced Xerostomia: A Review.Journal of oncology · 2022Review
- Artificial Saliva for Therapeutic Management of Xerostomia: A Narrative Review.Journal of pharmacy & bioallied sciences · 2021Review
- Mechanism, Prevention, and Treatment of Radiation-Induced Salivary Gland Injury Related to Oxidative Stress.Antioxidants (Basel, Switzerland) · 2021Review
- Article
- Artificial Saliva: Challenges and Future Perspectives for the Treatment of Xerostomia.International journal of molecular sciences · 2019Review
- Transplantation of Bone Marrow-Derived Mesenchymal Stem Cells Preserve the Salivary Glands Structure after Head and Neck Radiation in Rats.Open access Macedonian journal of medical sciences · 2019Article
- Localized Delivery of Amifostine Enhances Salivary Gland Radioprotection.Journal of dental research · 2018Article
- Artificial Induction of Native Aquaporin-1 Expression in Human Salivary Cells.Journal of dental research · 2017Article
- Radioprotective effects of Keratinocyte Growth Factor-1 against irradiation-induced salivary gland hypofunction.Oncotarget · 2017Article
- Three-Dimensional Bioprinting Nanotechnologies towards Clinical Application of Stem Cells and Their Secretome in Salivary Gland Regeneration.Stem cells international · 2016Review
- Ultrasound-assisted nonviral gene transfer of AQP1 to the irradiated minipig parotid gland restores fluid secretion.Gene therapy · 2015Article
- Proteomic profiling of salivary gland after nonviral gene transfer mediated by conventional plasmids and minicircles.Molecular therapy. Methods & clinical development · 2014Article
- Adult stem cells and tissue engineering strategies for salivary gland regeneration: a review.Biomaterials research · 2014Review
- Cost-effectiveness landscape analysis of treatments addressing xerostomia in patients receiving head and neck radiation therapy.Oral surgery, oral medicine, oral pathology and oral radiology · 2013Review
- Gross Cystic Disease Fluid Protein-15(GCDFP-15)/Prolactin-Inducible Protein (PIP) as Functional Salivary Biomarker for Primary Sjögren's Syndrome.Journal of genetic syndromes & gene therapy · 2013Article
- Article
- Radioprotective effect of lidocaine on neurotransmitter agonist-induced secretion in irradiated salivary glands.PloS one · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
A significant long-term side effect of radiation therapy for head and neck cancers is xerostomia, a dry mouth, due to salivary gland damage. Despite continuing efforts to eliminate this problem, many patients continue to suffer. This brief review describes our efforts to develop a gene transfer approach, employing the aquaporin-1 cDNA, to treat patients with existing radiation-induced salivary hypofunction. A Phase I/II clinical trial, using a recombinant adenoviral vector to mediate gene transfer, is currently underway.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.