ArticleBiomaterials2010
Promotion of osteoblast proliferation on complex coacervation-based hyaluronic acid - recombinant mussel adhesive protein coatings on titanium.
Article in Biomaterials, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 110 citations in OpenAlex.
- Biomimetic Coacervate Coatings: From Phase Separation Fundamentals to Advanced Biomedical Applications.Biomimetics (Basel, Switzerland) · 2026Review
- Design and applications of synthetic biomolecular condensates.Nature nanotechnology · 2026Review
- Review
- Sticky Science: Using Complex Coacervate Adhesives for Biomedical Applications.Advanced healthcare materials · 2025Review
- Covalent immobilization of VEGF on allogeneic bone through polydopamine coating to improve bone regeneration.Frontiers in bioengineering and biotechnology · 2022Article
- Looping-in complexation and ion partitioning in nonstoichiometric polyelectrolyte mixtures.Science advances · 2021Article
- Mussel adhesive protein blended with gelatin loaded into nanotube titanium dental implants enhances osseointegration.Drug delivery and translational research · 2021Article
- The Influence of Hyaluronic Acid Biofunctionalization of a Bovine Bone Substitute on Osteoblast Activity In Vitro.Materials (Basel, Switzerland) · 2021Article
- Biocompatible and Biomaterials Application in Drug Delivery System in Oral Cavity.Evidence-based complementary and alternative medicine : eCAM · 2021Review
- Exploiting mammalian low-complexity domains for liquid-liquid phase separation-driven underwater adhesive coatings.Science advances · 2019Article
- Upper Critical Solution Temperature (UCST) Behavior of Coacervate of Cationic Protamine and Multivalent Anions.Polymers · 2019Article
- A biocompatible betaine-functionalized polycation for coacervation.Soft matter · 2018Article
- Rapamycin/sodium hyaluronate binding on nano-hydroxyapatite coated titanium surface improves MC3T3-E1 osteogenesis.PloS one · 2017Article
- Mussel Coating Protein-Derived Complex Coacervates Mitigate Frictional Surface Damage.ACS biomaterials science & engineering · 2015Article
- Infiltration of chitin by protein coacervates defines the squid beak mechanical gradient.Nature chemical biology · 2015Article
- In-situ formation of growth-factor-loaded coacervate microparticle-embedded hydrogels for directing encapsulated stem cell fate.Advanced materials (Deerfield Beach, Fla.) · 2015Article
- The chemistry of stalked barnacle adhesive (Lepas anatifera).Interface focus · 2015Article
- Coacervate delivery systems for proteins and small molecule drugs.Expert opinion on drug delivery · 2014Review
- A mussel-derived one component adhesive coacervate.Acta biomaterialia · 2014Article
- Mussel-inspired human gelatin nanocoating for creating biologically adhesive surfaces.International journal of nanomedicine · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Many biological polyelectrolytes are capable of undergoing a fluid-fluid phase separation known as complex coacervation. Coacervates were prepared using hyaluronic acid (HA) and a recombinant fusion protein consisting of mussel adhesive motifs and the RGD peptide (fp-151-RGD). The low interfacial energy of the coacervate was exploited to coat titanium (Ti), a metal widely used in implant materials. The coacervate effectively distributed both HA and fp-151-RGD over the Ti surfaces and enhanced osteoblast proliferation. Approximately half of total fp-151-RGD and HA in the solution transferred to the titanium surface within 2h. Titanium coated with coacervates having high residual negative surface charge showed the highest cell proliferation of preosteoblast cells (MC-3T3) compared to the treatments tested. Indeed, MC-3T3 cells on complex coacervate coated titanium foils exhibited over 5 times greater cell proliferation than bare, HA coated or fp-151-RGD coated titanium.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.