Trial reportPsychological medicine2010
A controlled family study of children with DSM-IV bipolar-I disorder and psychiatric co-morbidity.
Trial report in Psychological medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Further evidence for robust familiality of pediatric bipolar I disorder: results from a very large controlled family study of pediatric bipolar I disorder and a meta-analysis.The Journal of clinical psychiatry · 2012Pooled it
- Further evidence that pediatric-onset bipolar disorder comorbid with ADHD represents a distinct subtype: results from a large controlled family study.Journal of psychiatric research · 2013Trial
- Regional cerebellar structural deficits distinguish psychostimulant-free ADHD youth with and without familial risk for bipolar I disorder: a cross-sectional morphometric analysis.Journal of child psychology and psychiatry, and allied disciplines · 2026Article
- Comorbidity and patterns of familial aggregation in attention-deficit/hyperactivity disorder and bipolar disorder in a family study of affective and anxiety spectrum disorders.Journal of psychiatric research · 2020Article
- A systematic review of the frequency and severity of manic symptoms reported in studies that compare phenomenology across children, adolescents and adults with bipolar disorders.International journal of bipolar disorders · 2017Review
- Similar familial underpinnings for full and subsyndromal pediatric bipolar disorder: A familial risk analysis.Bipolar disorders · 2017Article
- Attention deficit hyperactivity disorder in children with early stages of chronic kidney disease.Medical journal of the Islamic Republic of Iran · 2015Article
- Further evidence that severe scores in the aggression/anxiety-depression/attention subscales of child behavior checklist (severe dysregulation profile) can screen for bipolar disorder symptomatology: a conditional probability analysis.Journal of affective disorders · 2014Article
- Independence of familial transmission of mania and depression: results of the NIMH family study of affective spectrum disorders.Molecular psychiatry · 2014Article
- Maternal smoking during pregnancy and bipolar disorder in offspring.The American journal of psychiatry · 2013Article
- Bipolar disorder in children and adolescents.Child and adolescent mental health · 2013Article
- Can pediatric bipolar-I disorder be diagnosed in the context of posttraumatic stress disorder? A familial risk analysis.Psychiatry research · 2013Article
- Does sex moderate the clinical correlates of pediatric bipolar-I disorder? Results from a large controlled family-genetic study.Journal of affective disorders · 2013Article
- Personal and familial correlates of bipolar (BP)-I disorder in children with a diagnosis of BP-I disorder with a positive child behavior checklist (CBCL)-severe dysregulation profile: a controlled study.Journal of affective disorders · 2013Article
- Family-based association study of early growth response gene 3 with child bipolar I disorder.Journal of affective disorders · 2012Article
- Toward defining deficient emotional self-regulation in children with attention-deficit/hyperactivity disorder using the Child Behavior Checklist: a controlled study.Postgraduate medicine · 2011Article
- Severe mood dysregulation, irritability, and the diagnostic boundaries of bipolar disorder in youths.The American journal of psychiatry · 2011Article
- Antisocial personality and bipolar disorder: interactions in impulsivity and course of illness.Neuropsychiatry · 2011Article
- Clinical characteristics of comorbid obsessive-compulsive disorder and bipolar disorder in children and adolescents.Bipolar disorders · 2010Article
- Tools to improve differential diagnosis of bipolar disorder in primary care.Primary care companion to the Journal of clinical psychiatry · 2010Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundTo estimate the spectrum of familial risk for psychopathology in first-degree relatives of children with unabridged DSM-IV bipolar-I disorder (BP-I).
methodWe conducted a blinded, controlled family study using structured diagnostic interviews of 157 children with BP-I probands (n=487 first-degree relatives), 162 attention deficit hyperactivity disorder (ADHD) (without BP-I) probands (n=511 first-degree relatives), and 136 healthy control (without ADHD or BP-I) probands (n=411 first-degree relatives).
resultsThe morbid risk (MR) of BP-I disorder in relatives of BP-I probands (MR=0.18) was increased 4-fold [95% confidence interval (CI) 2.3-6.9, p<0.001] over the risk to relatives of control probands (MR=0.05) and 3.5-fold (95% CI 2.1-5.8, p<0.001) over the risk to relatives of ADHD probands (MR=0.06). In addition, relatives of children with BP-I disorder had high rates of psychosis, major depression, multiple anxiety disorders, substance use disorders, ADHD and antisocial disorders compared with relatives of control probands. Only the effect for antisocial disorders lost significance after accounted for by the corresponding diagnosis in the proband. Familial rates of ADHD did not differ between ADHD and BP-I probands.
conclusionsOur results document an increased familial risk for BP-I disorder in relatives of pediatric probands with DSM-IV BP-I. Relatives of probands with BP-I were also at increased risk for other psychiatric disorders frequently associated with pediatric BP-I. These results support the validity of the diagnosis of BP-I in children as defined by DSM-IV. More work is needed to better understand the nature of the association between these disorders in probands and relatives.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.