ArticleCritical care (London, England)2009
Association of mannose-binding lectin-2 genotype and serum levels with prognosis of sepsis.
Article in Critical care (London, England), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 4 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Association between the TLR2 Arg753Gln polymorphism and the risk of sepsis: a meta-analysis.Critical care (London, England) · 2015Pooled it
- Relationship of serum mannose-binding lectin levels with the development of sepsis: a meta-analysis.Inflammation · 2015Pooled it
- Mannose-binding lectin polymorphisms and the risk of sepsis: evidence from a meta-analysis.Epidemiology and infection · 2014Pooled it
- Mannose-binding lectin codon 54 gene polymorphism and vulvovaginal candidiasis: a systematic review and meta-analysis.BioMed research international · 2014Pooled it
- Mannose-Binding Lectin Levels in Critically Ill Children With Severe Infections.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2017Trial
- Association of MBL2 gene polymorphisms and MBL levels with dilated cardiomyopathy in a Chinese Han population.BMC medical genomics · 2024Article
- Role ofDiagnostics (Basel, Switzerland) · 2022Article
- Levels of mannose-binding lectin (MBL) associates with sepsis-related in-hospital mortality in women.Journal of inflammation (London, England) · 2020Article
- Use of Mannose-Binding Lectin Gene Polymorphisms and the Serum MBL Level for the Early Detection of Neonatal Sepsis.Journal of pediatric genetics · 2018Article
- Serial Changes in Mannose-Binding Lectin in Patients with Sepsis.Tuberculosis and respiratory diseases · 2018Article
- Mannose-Binding Lectin Gene Polymorphism and Its Association with Susceptibility to Recurrent Vulvovaginal Candidiasis.BioMed research international · 2018Article
- Fc Gamma Receptor IIA (CD32A) R131 Polymorphism as a Marker of Genetic Susceptibility to Sepsis.Inflammation · 2016Article
- The role of MBL2 gene polymorphism in sepsis incidence.International journal of clinical and experimental pathology · 2015Article
- Association of mannose-binding lectin 2 gene polymorphisms with persistent Staphylococcus aureus bacteremia.PloS one · 2014Article
- The role of mannose-binding lectin in severe sepsis and septic shock.Mediators of inflammation · 2013Review
- Association of genetic variants in the IRAK-4 gene with susceptibility to severe sepsis.World journal of emergency medicine · 2012Article
- Variants in the Toll-interacting protein gene are associated with susceptibility to sepsis in the Chinese Han population.Critical care (London, England) · 2011Article
- Changes in Mannose-Binding Lectin and Collectin Kidney 1 Levels in Sepsis Patients With and Without Disseminated Intravascular Coagulation.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisArticle
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionIndividuals deficient in mannose-binding lectin (MBL), an important component of the innate immune system, show increased susceptibility to infection. We investigated whether polymorphisms in the MBL2 gene and the serum level are associated with the severity and prognosis of sepsis.
methodsA total of 266 patients with sepsis and 398 healthy controls were enrolled. We analyzed the three single nucleotide polymorphisms (Gly54Asp, -550, and +4) in the MBL2 gene. Serum samples collected on day 1 were analyzed for the levels of MBL.
resultsPatients who were heterozygous (A/B) or homozygous (B/B) at codon 54 (adjusted odds ratio (OR), 0.370; 95% confidence interval (CI), 0.207-0.661, P = 0.001) and who were heterozygous (H/L) or homozygous (L/L) at -550 (adjusted OR, 0.476; 95% CI, 0.249-0.910, P = 0.025) were less likely to have septic shock in the sepsis group. Using Cox regression analysis for 28-day mortality, an MBL level > or = 1.3 microg/mL showed significantly lower 28-day mortality (P = 0.020; hazard ratio, 0.571; 95% CI, 0.355-0.916) in the septic shock group.
conclusionsHomozygosity at codons 54 (A/A) and -550 (H/H) appears to be associated with the severity, but not the outcome, of sepsis, whereas a low MBL level may be an independent risk factor for mortality. These findings suggest that the genotype and serum level for MBL2 may have different clinical implications.
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