ReviewParasite immunology2009
Dysregulation of macrophage signal transduction by Toxoplasma gondii: past progress and recent advances.
Review in Parasite immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- The opposing effect of acute and chronic Toxoplasma gondii infection on tumor development.Parasites & vectors · 2024Article
- Parasite-induced IFN-γ regulates host defense via CD115 and mTOR-dependent mechanism of tissue-resident macrophage death.PLoS pathogens · 2024Article
- The Role of microRNAs in the Infection byFrontiers in cellular and infection microbiology · 2021Review
- Production of Inflammatory Cytokines and Nitric Oxide by Human Mast Cells Incubated with Toxoplasma gondii Lysate.The Korean journal of parasitology · 2019Article
- Comparison of splenocyte microRNA expression profiles of pigs during acute and chronic toxoplasmosis.BMC genomics · 2019Article
- Sources of Type I Interferons in Infectious Immunity: Plasmacytoid Dendritic Cells Not Always in the Driver's Seat.Frontiers in immunology · 2019Review
- Article
- Recolonizing gray wolves increase parasite infection risk in their prey.Ecology and evolution · 2018Article
- Article
- The Effect of TGF-β on Treg Cells in Adverse Pregnancy Outcome uponFrontiers in microbiology · 2017Article
- MicroRNAs in the Host-Apicomplexan Parasites Interactions: A Review of Immunopathological Aspects.Frontiers in cellular and infection microbiology · 2016Review
- Innate immunity to Toxoplasma gondii infection.Nature reviews. Immunology · 2014Review
- Changes of inhibitory receptors on NK-92 cells and HLA-G on BeWo cells with Toxoplasma gondii infection.Inflammation · 2013Article
- SAG2A protein from Toxoplasma gondii interacts with both innate and adaptive immune compartments of infected hosts.Parasites & vectors · 2013Article
- Toxoplasma gondii-induced activation of EGFR prevents autophagy protein-mediated killing of the parasite.PLoS pathogens · 2013Article
- Toxoplasma gondii infection regulates the balance of activating and inhibitory receptors on decidual natural killer cells.PloS one · 2013Article
- Toxoplasma gondii inhibits mast cell degranulation by suppressing phospholipase Cγ-mediated Ca(2+) mobilization.Frontiers in microbiology · 2013Article
- Modulation of activation-associated host cell gene expression by the apicomplexan parasite Theileria annulata.Cellular microbiology · 2012Article
- Insights into inflammatory bowel disease using Toxoplasma gondii as an infectious trigger.Immunology and cell biology · 2012Review
- Epigenetic regulation of tumor necrosis factor α (TNFα) release in human macrophages by HIV-1 single-stranded RNA (ssRNA) is dependent on TLR8 signaling.The Journal of biological chemistry · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The opportunistic protozoan parasite Toxoplasma gondii is well known as a strong inducer of cell-mediated immunity, largely as a result of proinflammatory cytokine induction during in vivo infection. Yet, during intracellular infection the parasite suppresses signal transduction pathways leading to these proinflammatory responses. The opposing responses are likely to reflect the parasite's need to stimulate immunity allowing host survival and parasite persistence, and at the same time avoiding excessive responses that could result in parasite elimination and host immunopathology. This Review summarizes past and present investigations into the effects of Toxoplasma on host cell signal transduction. These studies reveal insight into the profound suppression of proinflammatory cytokine responses that occurs when the parasite infects macrophages and other cells of innate immunity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.