ReviewMass spectrometry reviews
The role of mass spectrometry-based metabolomics in medical countermeasures against radiation.
Review in Mass spectrometry reviews. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- Prediction of in vivo radiation dose status in radiotherapy patients using ex vivo and in vivo gene expression signatures.Radiation research · 2011Trial
- Longitudinal metabolic alterations in plasma of rats exposed to low doses of high linear energy transfer radiation.Journal of environmental science and health. Part C, Toxicology and carcinogenesis · 2021Article
- Effect of Sex on Biomarker Response in a Mouse Model of the Hematopoietic Acute Radiation Syndrome.Health physics · 2019Article
- Metabolomic applications in radiation biodosimetry: exploring radiation effects through small molecules.International journal of radiation biology · 2017Review
- Metabolomic Analysis of Mice Exposed to Gamma Radiation Reveals a Systemic Understanding of Total-Body Exposure.Radiation research · 2017Article
- Rapid and High-Throughput Detection and Quantitation of Radiation Biomarkers in Human and Nonhuman Primates by Differential Mobility Spectrometry-Mass Spectrometry.Journal of the American Society for Mass Spectrometry · 2016Article
- Mass Spectrometry-Based Metabolomics Identifies Longitudinal Urinary Metabolite Profiles Predictive of Radiation-Induced Cancer.Cancer research · 2016Article
- Modulation of Radiation Response by the Tetrahydrobiopterin Pathway.Antioxidants (Basel, Switzerland) · 2015Review
- Application of mass spectrometry-based metabolomics in identification of early noninvasive biomarkers of alcohol-induced liver disease using mouse model.Advances in experimental medicine and biology · 2015Article
- Article
- Liver metabolomics reveals increased oxidative stress and fibrogenic potential in gfrp transgenic mice in response to ionizing radiation.Journal of proteome research · 2014Article
- Long-term differential changes in mouse intestinal metabolomics after γ and heavy ion radiation exposure.PloS one · 2014Article
- Identification and quantitation of biomarkers for radiation-induced injury via mass spectrometry.Health physics · 2014Article
- Assessment of biodosimetry methods for a mass-casualty radiological incident: medical response and management considerations.Health physics · 2013Article
- Review: toxicometabolomics.Journal of applied toxicology : JAT · 2013Review
- Metabolomic changes in gastrointestinal tissues after whole body radiation in a murine model.Molecular bioSystems · 2013Article
- Stable isotope- and mass spectrometry-based metabolomics as tools in drug metabolism: a study expanding tempol pharmacology.Journal of proteome research · 2013Article
- Metabolomics: an essential tool to understand the function of peroxisome proliferator-activated receptor alpha.Toxicologic pathology · 2013Review
- Comparison of mouse urinary metabolic profiles after exposure to the inflammatory stressors γ radiation and lipopolysaccharide.Radiation research · 2012Article
- Xenobiotic metabolomics: major impact on the metabolome.Annual review of pharmacology and toxicology · 2012Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Radiation metabolomics can be defined as the global profiling of biological fluids to uncover latent, endogenous small molecules whose concentrations change in a dose-response manner following exposure to ionizing radiation. In response to the potential threat of nuclear or radiological terrorism, the Center for High-Throughput Minimally Invasive Radiation Biodosimetry was established to develop field-deployable biodosimeters based, in part, on rapid analysis by mass spectrometry of readily and easily obtainable biofluids. In this review, we briefly summarize radiation biology and key events related to actual and potential nuclear disasters, discuss the important contributions the field of mass spectrometry has made to the field of radiation metabolomics, and summarize current discovery efforts to use mass spectrometry-based metabolomics to identify dose-responsive urinary constituents, and ultimately to build and deploy a noninvasive high-throughput biodosimeter.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.