ArticleLipids2010
Early and sustained enrichment of serum n-3 long chain polyunsaturated fatty acids in dogs fed a flaxseed supplemented diet.
Article in Lipids, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed, 29 citations in OpenAlex.
- Fatty acid patterns of dog erythrocyte membranes after feeding of a fish-oil based DHA-rich supplement with a base diet low in n-3 fatty acids versus a diet containing added n-3 fatty acids.Acta veterinaria Scandinavica · 2011Trial
- Serum Metabolomics of Senior Dogs Fed a Fresh, Human-Grade Food or an Extruded Kibble Diet.Metabolites · 2025Article
- The Effect of Ethyl Esters of Linseed Oil on the Changes in the Fatty Acid Profile of Hair Coat Sebum, Blood Serum and Erythrocyte Membranes in Healthy Dogs.Animals : an open access journal from MDPI · 2023Article
- Dietary Ground Flaxseed Increases Serum Alpha-Linolenic Acid Concentrations in Adult Cats.Animals : an open access journal from MDPI · 2022Article
- Roles of plant-based ingredients and phytonutrients in canine nutrition and health.Journal of animal physiology and animal nutrition · 2022Review
- Dietary Betaine and Fatty Acids Change Circulating Single-Carbon Metabolites and Fatty Acids in the Dog.Animals : an open access journal from MDPI · 2022Article
- The associations between serum adiponectin, leptin, C-reactive protein, insulin, and serum long-chain omega-3 fatty acids in Labrador Retrievers.Veterinary medicine (Auckland, N.Z.) · 2015Article
- Lipid metabolic dose response to dietary alpha-linolenic acid in monk parrot (Myiopsitta monachus).Lipids · 2014Article
- Dietary gamma-linolenic acid supports arachidonic acid accretion and associated Δ-5 desaturase activity in feline uterine but not ovarian tissues.Journal of nutritional science · 2014Article
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Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A study was conducted in dogs to assess n-3 long chain polyunsaturated fatty acid incorporation after feeding an alpha-linolenic (ALA)-rich flaxseed supplemented diet (FLX) for 84 days. Serum total phospholipids (PL), triacylglycerol (TG), and cholesteryl esters (CE) were isolated at selected times and fatty acid methyl esters were analyzed. Increased LA was seen in the FLX-PL fraction after 28 days and an expected decrease in PL-AA. Enrichment of ALA, eicosapentaenoic acid (EPA) and docosapentaenoic acid n-3 (DPAn-3) in the FLX-group occurred early on (day 4) in both PL and TG fractions but no docosahexaenoic acid (DHA) was found, consistent with data from other species including humans. In contrast, no accumulation of DPAn-3 was seen in serum-CE, suggesting that this fatty acid does not participate in reverse-cholesterol transport. The accumulation of DPAn-3 in fasting PL and TG fractions is likely due to post-absorptive secretion after tissue synthesis. Because conversion of DPAn-3 to DHA occurs in canine neurologic tissues, this DPAn-3 may provide a circulating reservoir for DHA synthesis in such tissues. The absence of DPAn-3 in serum-CE suggests that such transport may be unidirectional. Although conversion of DPAn-3 to DHA is slow in most species, one-way transport of DPAn-3 in the circulation may help conserve this fatty acid as a substrate for DHA synthesis in brain and retinal tissues especially when dietary intakes of DHA are low.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.