Trial reportJournal of perinatology : official journal of the California Perinatal Association2010
Effectiveness of No-Sting skin protectant and Aquaphor on water loss and skin integrity in premature infants.
Trial report in Journal of perinatology : official journal of the California Perinatal Association, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 6 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Topical application of emollients to maintain skin integrity in preterm neonates: a systematic review and meta-analysis.European journal of pediatrics · 2026Pooled it
- Skin care interventions in infants for preventing eczema and food allergy.The Cochrane database of systematic reviews · 2022Pooled it
- Topical emollient for preventing infection in preterm infants.The Cochrane database of systematic reviews · 2021Pooled it
- Skin care interventions in infants for preventing eczema and food allergy.The Cochrane database of systematic reviews · 2021Pooled it
- Topical emollient for preventing infection in preterm infants.The Cochrane database of systematic reviews · 2016Pooled it
- Potential NICU Environmental Influences on the Neonate's Microbiome: A Systematic Review.Advances in neonatal care : official journal of the National Association of Neonatal Nurses · 2015Pooled it
- Randomized, controlled trial evaluating a baby wash product on skin barrier function in healthy, term neonates.Journal of obstetric, gynecologic, and neonatal nursing : JOGNNTrial
- Seeing beyond the obvious: pragmatic skin care guidance for infants 22-24 weeks gestational age.Journal of perinatology : official journal of the California Perinatal Association · 2025Review
- Thermoregulation, incubator humidity, and skincare practices in appropriate for gestational age ultra-low birth weight infants: need for more evidence.World journal of pediatrics : WJP · 2024Review
- The Science of Skin: Measuring Damage and Assessing Risk.Advances in wound care · 2023Review
- Global variation in skin injures and skincare practices in extremely preterm infants.World journal of pediatrics : WJP · 2023Article
- Recommendation for hygiene and topical in neonatology from the French Neonatal Society.European journal of pediatrics · 2019Article
- Tolerance of natural baby skin-care products on healthy, full-term infants and toddlers.Clinical, cosmetic and investigational dermatology · 2014Article
- Tolerance of skin care regimen in healthy, full-term neonates.Clinical, cosmetic and investigational dermatology · 2013Article
- The infant skin barrier: can we preserve, protect, and enhance the barrier?Dermatology research and practice · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe purpose of this study was to evaluate the effects of No-Sting skin protectant and Aquaphor, a water-based emollient, on skin integrity measured by Neonatal Skin Condition Score (NSCS) and transepidermal water loss (TEWL) in premature infants. In addition, with no data regarding the use of No-Sting in the neonatal population and its desirability because it requires less infant manipulation and less nursing time, it was important to evaluate the use of this product. STUDY
designIn all, 69 premature infants born at <33 weeks gestation were randomly assigned to one of the two treatment groups: (1) No-Sting or (2) Aquaphor for a total of 14 days.
resultGestational age and total fluid intake were related to NSCS whereas gestational age, incubator humidity levels and total daily fluid intake were significantly related to TEWL. Infants receiving Aquaphor had significantly higher NSCS, but the mean scores in both groups over the 14-day period were in the normal range (<4). There were no differences between Aquaphor and No-Sting in the rate of TEWL over the 14-day period.
conclusionThis study provides the first information regarding the use of No-Sting in the neonatal population. This skin protectant seems as effective as Aquaphor in decreasing TEWL and maintaining skin integrity, and is less resource intensive.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.