Evidence map›Paper›PMID 19890125›Full record

Trial reportThe New England journal of medicine2009

On-pump versus off-pump coronary-artery bypass surgery.

A Laurie Shroyer, Frederick L Grover, Brack Hattler, Joseph F Collins, Gerald O McDonald, Elizabeth Kozora, John C Lucke, Janet H Baltz, Dimitri Novitzky, Veterans Affairs Randomized On/Off Bypass (ROOBY) Study Group

3 registry-linked trialsAbstract readComparative StudyMulticenter StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in The New England journal of medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 245 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
245citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03542110 phase4terminatedstarted 2018, after this paper: background citation

Effect of Alirocumab on Saphenous Vein Graft Atherosclerosis: The Alirocumab for Stopping Atherosclerosis Progression in Saphenous Vein Grafts (ASAP-SVG) Pilot Trial

Ran2018Enrolled46Registered outcomes4Posted comparisons0ConditionsSaphenous Vein Graft AtherosclerosisArmsAlirocumab 150 MG/ML subcutaneous injection, Matching Placebo subcutaneous injection
PMID 26429851PMID 17697821PMID 21768550PMID 19884468PMID 19778774PMID 18841653PMID 16287955PMID 15582312PMID 12595843PMID 11092659PMID 24643432PMID 29759512other papers from this trial
Open the trial in the graph
NCT00032630 phase3completednot on this map

CSP #517 - Outcomes Following Myocardial Revascularization: On and Off Cardiopulmonary Bypass

TypeinterventionalSponsorUS Department of Veterans AffairsRan2002 to 2008Enrolled2,203ConditionsIschemic Heart DiseaseArmsCoronary artery bypass - on-pump, Coronary artery bypass - off-pump
NCT01290952 phase4completednot on this map

ON Pump vs OFF Pump Myocardial Revascularization in High Risk Patients: a Randomized Study

TypeinterventionalSponsorMedtronic ItaliaRan2006 to 2011Enrolled411ConditionsCoronary Artery DiseaseArmsOff-pump bypass surgery, On-pump bypass surgery
3 · Its place in the literature

Who cites it

245 citing papers in PubMed, 10 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Perioperative Clinical Trials in AKI.Seminars in nephrology · 2020
    Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Trial
  12. Trial
  13. Trial
  14. Trial
  15. Trial
  16. Trial
  17. Trial
  18. Trial
  19. Trial
  20. Trial

185 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

A Laurie ShroyerNorthport Veterans Affairs (VA) Medical Center, Northport, NY, USA.
Frederick L Grover
Brack Hattler
Joseph F Collins
Gerald O McDonald
Elizabeth Kozora
John C Lucke
Janet H Baltz
Dimitri Novitzky
Veterans Affairs Randomized On/Off Bypass (ROOBY) Study Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCoronary-artery bypass grafting (CABG) has traditionally been performed with the use of cardiopulmonary bypass (on-pump CABG). CABG without cardiopulmonary bypass (off-pump CABG) might reduce the number of complications related to the heart-lung machine.

methodsWe randomly assigned 2203 patients scheduled for urgent or elective CABG to either on-pump or off-pump procedures. The primary short-term end point was a composite of death or complications (reoperation, new mechanical support, cardiac arrest, coma, stroke, or renal failure) before discharge or within 30 days after surgery. The primary long-term end point was a composite of death from any cause, a repeat revascularization procedure, or a nonfatal myocardial infarction within 1 year after surgery. Secondary end points included the completeness of revascularization, graft patency at 1 year, neuropsychological outcomes, and the use of major resources.

resultsThere was no significant difference between off-pump and on-pump CABG in the rate of the 30-day composite outcome (7.0% and 5.6%, respectively; P=0.19). The rate of the 1-year composite outcome was higher for off-pump than for on-pump CABG (9.9% vs. 7.4%, P=0.04). The proportion of patients with fewer grafts completed than originally planned was higher with off-pump CABG than with on-pump CABG (17.8% vs. 11.1%, P<0.001). Follow-up angiograms in 1371 patients who underwent 4093 grafts revealed that the overall rate of graft patency was lower in the off-pump group than in the on-pump group (82.6% vs. 87.8%, P<0.01). There were no treatment-based differences in neuropsychological outcomes or short-term use of major resources.

conclusionsAt 1 year of follow-up, patients in the off-pump group had worse composite outcomes and poorer graft patency than did patients in the on-pump group. No significant differences between the techniques were found in neuropsychological outcomes or use of major resources. (ClinicalTrials.gov number, NCT00032630.).

Indexed as

Coronary Artery BypassCoronary Artery Bypass, Off-PumpCoronary DiseaseFemaleFollow-Up StudiesGraft Occlusion, VascularHealth ResourcesHumansKaplan-Meier EstimateMaleMemory DisordersMiddle AgedNeuropsychological TestsPostoperative ComplicationsSingle-Blind MethodTreatment Outcome

Identifiers

PMID19890125

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.