ArticleThe Journal of clinical endocrinology and metabolism2009
Effect of body mass index on peak growth hormone response to provocative testing in children with short stature.
Article in The Journal of clinical endocrinology and metabolism, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diagnosis, Genetics, and Therapy of Short Stature in Children: A Growth Hormone Research Society International Perspective.Hormone research in paediatrics · 2019Guideline
- Effect of recombinant human growth hormone on liver fat content in young adults with nonalcoholic fatty liver disease.Clinical endocrinology · 2021Trial
- Transcriptomics and machine learning predict diagnosis and severity of growth hormone deficiency.JCI insight · 2018Trial
- A pilot study of the effects of niacin administration on free fatty acid and growth hormone concentrations in children with obesity.Pediatric obesity · 2018 · on this mapTrial
- Predicting the probability of abnormal stimulated growth hormone response in children after radiotherapy for brain tumors.International journal of radiation oncology, biology, physics · 2012Trial
- Nutritional Status of Children with Short Stature Is Oppositely Associated with Growth Hormone Peak in Stimulation Tests and Insulin-like Growth Factor-1 Concentration.Journal of clinical medicine · 2026Article
- Obesity-Related Changes in Growth Hormone Stimulation Test Performance Under Pediatric Growth Hormone Deficiency.Children (Basel, Switzerland) · 2026Article
- Consensus and controversies about diagnosing GH deficiency: a Delphi survey by the GH research society.Pituitary · 2025Review
- Development and Validation of a Clinical Prediction Model for Growth Hormone Deficiency in Children with Short Stature: A Retrospective Study in China.Journal of multidisciplinary healthcare · 2025Article
- Auxological parameters associated with the diagnosis of growth hormone deficiency in children with short stature.Pediatric endocrinology, diabetes, and metabolism · 2025Article
- Accuracy of Glucagon Testing Across Transition in Young Adults With Childhood-Onset GH Deficiency.The Journal of clinical endocrinology and metabolism · 2024Article
- Reliability of Agreement between Insulin, Clonidine, and Glucagon Stimulation Tests for the Diagnosis of Growth Hormone Deficiency in Children: A Retrospective Cohort Study.Children (Basel, Switzerland) · 2023Article
- Relationship between the Stimulated Peak Growth Hormone Level and Metabolic Parameters in Children with Growth Hormone Deficiency.Ewha medical journal · 2023Article
- Diagnosis of childhood and adolescent growth hormone deficiency using transcriptomic data.Frontiers in endocrinology · 2023Article
- Article
- Response of multiple hormones to glucose and arginine challenge in T2DM after gastric bypass.Endocrine connections · 2022Article
- Effect of body mass index on peak growth hormone level after growth hormone stimulation test in children with short stature.Annals of pediatric endocrinology & metabolism · 2021Article
- Provocative growth hormone testing in children: how did we get here and where do we go now?Journal of pediatric endocrinology & metabolism : JPEM · 2021Review
- Association between triglyceride glucose index and peak growth hormone in children with short stature.Scientific reports · 2021Article
- Deciphering short stature in children.Annals of pediatric endocrinology & metabolism · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
contextObesity is associated with decreased spontaneous and stimulated GH secretion, but the effect of body mass index (BMI) on results of GH stimulation testing in children with short stature is not known.
objectiveThe aim of the study was to determine the impact of BMI on peak GH to provocative testing in children with short stature. DESIGN, SETTING, AND
participantsThis was a retrospective review of provocative GH testing performed in 116 children 2-18 yr old in the ambulatory clinic of the Pediatric Endocrinology Unit at the Massachusetts General Hospital from 2004-2008.
main outcome measuresThe main outcome measure was peak stimulated GH. Height, weight, IGF-I, and IGF-binding protein 3 were also measured.
resultsIn univariate regression analysis, BMI sd score (BMI SDS) was inversely associated with natural log (ln) peak GH to provocative testing (P = 0.002), whereas height SDS, ln IGF-I, and IGF-binding protein 3 were not significantly associated with ln peak GH. After controlling for age, gender, BMI, and pubertal status, BMI (P = 0.002) remained independently associated with ln peak GH. BMI SDS significantly influenced the likelihood of diagnosis of GH deficiency using peak GH cutoffs of 10, 7, and 5 microg/liter.
conclusionIn children with short stature, BMI affects peak stimulated GH and should be considered when interpreting GH testing. Higher BMI SDS, even within the normal range, may lead to overdiagnosis of GH deficiency.
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