ArticleAmerican journal of physiology. Renal physiology2010
Altered whole kidney blood flow autoregulation in a mouse model of reduced beta-ENaC.
Article in American journal of physiology. Renal physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 44 citations in OpenAlex.
- Acid-sensing ion channels in the vasculature: emerging roles in systemic and pulmonary circulations.Pflugers Archiv : European journal of physiology · 2026Review
- Loss of βENaC Prevents Hepatic Steatosis but Promotes Abdominal Fat Deposition Associated with a High-Fat Diet.Biology · 2025Article
- The impact of Asic2 deletion on metabolic homeostasis in mice.Physiological reports · 2025Article
- Epithelial NaComprehensive Physiology · 2024Review
- Mice lacking ASIC2 and βENaC are protected from high-fat-diet-induced metabolic syndrome.Frontiers in endocrinology · 2024Article
- Epithelial sodium channels in macrophage migration and polarization: role of proinflammatory cytokines TNFα and IFNγ.American journal of physiology. Regulatory, integrative and comparative physiology · 2022Article
- Maladaptation of renal hemodynamics contributes to kidney dysfunction resulting from thoracic spinal cord injury in mice.American journal of physiology. Renal physiology · 2022Article
- Renal blood flow and oxygenation.Pflugers Archiv : European journal of physiology · 2022Review
- Is there a role of proinflammatory cytokines on degenerin-mediated cerebrovascular function in preeclampsia?Physiological reports · 2022Review
- βENaC and ASIC2 associate in VSMCs to mediate pressure-induced constriction in the renal afferent arteriole.American journal of physiology. Renal physiology · 2022Article
- Expression of Exogenous Epithelial Sodium Channel Beta Subunit in the Mouse Middle Cerebral Artery Increases Pressure-Induced Constriction.American journal of hypertension · 2021Article
- What Evolutionary Evidence Implies About the Identity of the Mechanoelectrical Couplers in Vascular Smooth Muscle Cells.Physiology (Bethesda, Md.) · 2021Review
- Interleukin-17 induces hypertension but does not impair cerebrovascular function in pregnant rats.Pregnancy hypertension · 2021Article
- Purinoceptors, renal microvascular function and hypertension.Physiological research · 2020Review
- Interleukin-17 Reduces βENaC via MAPK Signaling in Vascular Smooth Muscle Cells.International journal of molecular sciences · 2020Article
- Tumor necrosis factor-α impairs cerebral blood flow in pregnant rats: role of vascular β-epithelial NaAmerican journal of physiology. Heart and circulatory physiology · 2020Article
- Measurement of murine kidney functional biomarkers using DCE-MRI: A multi-slice TRICKS technique and semi-automated image processing algorithm.Magnetic resonance imaging · 2019Article
- Epithelial NaAnnual review of physiology · 2018Review
- Inositol 1,4,5-Trisphosphate Receptors in Hypertension.Frontiers in physiology · 2018Review
- Smooth Muscle Ion Channels and Regulation of Vascular Tone in Resistance Arteries and Arterioles.Comprehensive Physiology · 2017Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Renal blood flow (RBF) autoregulation is mediated by at least two mechanisms, the fast acting myogenic response (approximately 5 s) and slow acting tubuloglomerular feedback (TGF; approximately 25 s). Previous studies suggest epithelial Na(+) channel (ENaC) family proteins, beta-ENaC in particular, mediate myogenic constriction in isolated renal interlobar arteries. However, it is unknown whether beta-ENaC-mediated myogenic constriction contributes to RBF autoregulation in vivo. Therefore, the goal of this investigation was to determine whether the myogenic mediated RBF autoregulation is inhibited in a mouse model of reduced beta-ENaC (m/m). To address this goal, we evaluated the temporal response of RBF and renal vascular resistance (RVR) to a 2-min step increase in mean arterial pressure (MAP). Pressure-induced changes in RBF and RVR at 0-5, 6-25, and 110-120 s after step increase in MAP were used to assess the contribution of myogenic and TGF mechanisms and steady-state autoregulation, respectively. The rate of the initial increase in RVR, attributed to the myogenic mechanism, was reduced by approximately 50% in m/m mice, indicating the speed of the myogenic response was inhibited. Steady-state autoregulation was similar between beta-ENaC +/+ and m/m mice. Although the rate of the secondary increase in RVR, attributed to TGF, was similar in beta-ENaC +/+ and m/m mice, however, it occurred over a longer period (+10 s), which may have allowed TGF to compensate for a loss in myogenic autoregulation. Our findings suggest beta-ENaC is an important mediator of renal myogenic constriction-mediated RBF autoregulation in vivo.
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