Evidence map›Paper›PMID 19889933›Full record

ArticleThe Journal of general virology2010

Detection of norovirus-, sapovirus- and rhesus enteric calicivirus-specific antibodies in captive juvenile macaques.

Tibor Farkas, Jason Dufour, Xi Jiang, Karol Sestak

Open access · greenAbstract read
In one paragraph

Article in The Journal of general virology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 28 citations in OpenAlex.

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  5. The fecal virome of red-crowned cranes.Archives of virology · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Tibor FarkasCincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. Tibor.Farkas@cchmc.org
Jason Dufour
Xi Jiang
Karol Sestak
University of Cincinnati Medical Center · USTulane University · US

Funding

ZCM:A NOVEL BROAD-SPECTRUM MICROBICIDE FOR SEXUALLY TRANSMITTED INFECTIONSP51RR000164 · NCRR · TULANE UNIVERSITY OF LOUISIANA · PI MARX, PRESTON A · 1985 to 2011
$100.1M
Establishment and Expansion of SPF Rhesus ColonyU24RR018111 · NCRR · TULANE UNIVERSITY OF LOUISIANA · PI BOHM, RUDOLF PAUL · 2002 to 2011
$17.7M
ENTERIC VIRAL INFECTIONS OF CAPTIVE RHESUS MACAQUESR21RR024871 · NCRR · TULANE UNIVERSITY OF LOUISIANA · PI SESTAK, KAROL · 2008 to 2009
$379k
NCRR NIH HHS P51 RR000164NCRR NIH HHS P51RR000164-47NCRR NIH HHS R21 RR024871NCRR NIH HHS R21RR024871NCRR NIH HHS U24 RR018111
6 · The paper itself

Abstract

The objective of this study was to determine the prevalence of anti-norovirus (NoV), -sapovirus (SaV) and -Tulane virus (TV) antibodies in rhesus macaques of the Tulane National Primate Research Center and to evaluate the antigenic relationship between these viruses. A high prevalence of NoV-binding (51-61 %) and SaV-binding (50-56 %) antibodies and TV-neutralizing (69 %) antibodies were detected. Serum samples obtained during a human NoV outbreak and a multivalent anti-NoV hyperimmune serum were not able to neutralize TV infectivity. Conversely, low levels of cross-reactivity between the prototype TV and NoVs, but not between the TV and SaVs were detected by ELISA. These data indicate the preservation of some cross-reactive B-cell epitopes between the rhesus and human caliciviruses (CVs). The high prevalence of human and rhesus CV-specific serum antibodies suggests the frequent exposure of colony macaques to enteric CVs including the possibility of CV transmission between human and non-human primate hosts.

Indexed as

AnimalsAntibodies, NeutralizingAntibodies, ViralCaliciviridaeCaliciviridae InfectionsCross ReactionsHumansMacaca mulattaSeroepidemiologic StudiesAntibodies, NeutralizingAntibodies, Viral

Identifiers

PMID19889933
PMCPMC2888095
OpenAlexW1991544250

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.