Evidence map›Paper›PMID 19889894›Full record

ArticleJournal of clinical microbiology2010

Neosartorya udagawae (Aspergillus udagawae), an emerging agent of aspergillosis: how different is it from Aspergillus fumigatus?

J A Sugui, D C Vinh, G Nardone, Y R Shea, Y C Chang, A M Zelazny, K A Marr, S M Holland, K J Kwon-Chung

Open access · bronzeAbstract read
In one paragraph

Article in Journal of clinical microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 79 citations in OpenAlex.

  1. Article
  2. BeyondAntimicrobial agents and chemotherapy · 2026
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  3. Global epidemiology of azole resistance inJAC-antimicrobial resistance · 2026
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  6. Medical mycology case reports · 2024
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  7. Journal of fungi (Basel, Switzerland) · 2020
    Article
  8. Global Sexual Fertility in the Opportunistic PathogenJournal of fungi (Basel, Switzerland) · 2020
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. EmergingOpen forum infectious diseases · 2018
    Review
  14. Article
  15. Article
  16. Review
  17. Rodent Models of Invasive Aspergillosis due toFrontiers in microbiology · 2017
    Review
  18. Triazole Resistance in Aspergillus spp.: A Worldwide Problem?Journal of fungi (Basel, Switzerland) · 2016
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

J A SuguiLaboratory of Clinical Infectious Diseases, National Institutes of Health, 10 Center Drive, RM 11N234, Bethesda, MD 20892, USA.
D C Vinh
G Nardone
Y R Shea
Y C Chang
A M Zelazny
K A Marr
S M Holland
K J Kwon-Chung
National Institutes of Health · USITRI International · USJohns Hopkins Medicine · US

Funding

Transgenic Animal Models Of Human Immune DefectsZIAAI000646 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI HOLLAND, STEVEN · 2009 to 2025
$22.2M
Basic Studies On Aspergillus SpeciesZIAAI000657 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI KWON-CHUNG, KYUNG · 2009 to 2020
$4.3M
Antifungal Drug Resistance in AspergillusR21AI055928 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI MARR, KIEREN A. · 2003 to 2004
$507k
Genetic Diversity of A. fumigatusR21AI067971 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI MARR, KIEREN A. · 2006 to 2007
$439k
Molecular and Virulence Traits of Bacteria & Fungi Causing Persistent InfectionsZIACL080013 · CLC · CLINICAL CENTER · PI ZELAZNY, ADRIAN MARCELO · 2009 to 2025
$0k
CIHRIntramural NIH HHSNIAID NIH HHS R21 AI055928NIAID NIH HHS R21 AI067971
6 · The paper itself

Abstract

A recent report on several cases of invasive aspergillosis caused by Neosartorya udagawae suggested distinctive patterns of disease progression between N. udagawae and Aspergillus fumigatus. This prompted us to characterize N. udagawae in comparison to A. fumigatus. Our findings showed that both species exist in two mating types at similar ratios and produce gliotoxin. However, the thermotolerance of the two species differs: while A. fumigatus is able to grow at 55 degrees C but not at 10 degrees C, N. udagawae is able to grow at 10 degrees C but fails to grow at >42 degrees C. Furthermore, compared to A. fumigatus, the conidia of N. udagawae require longer incubation periods to germinate at 37 degrees C and are more susceptible to neutrophil attack as well as hydrogen peroxide; N. udagawae is also less virulent in gp91(phox-/-) mice. These findings suggest that growth and susceptibility to the host response might account for the reduced virulence of N. udagawae and the subtle distinction in the progression of the disease caused by the two species.

Indexed as

AnimalsAspergillosisAspergillus fumigatusCommunicable Diseases, EmergingDisease Models, AnimalHot TemperatureHumansHydrogen PeroxideMiceNeosartoryaVirulenceHydrogen Peroxide

Identifiers

PMID19889894
PMCPMC2812273
OpenAlexW2148832775

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.