ArticleJournal of leukocyte biology2010
Syk expression in peripheral blood leukocytes, CD34+ progenitors, and CD34-derived basophils.
Article in Journal of leukocyte biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Omalizumab increases the intrinsic sensitivity of human basophils to IgE-mediated stimulation.The Journal of allergy and clinical immunology · 2013Trial
- The safety and efficacy of sublingual and oral immunotherapy for milk allergy.The Journal of allergy and clinical immunology · 2012Trial
- Regulation of Syk kinase and FcRbeta expression in human basophils during treatment with omalizumab.The Journal of allergy and clinical immunology · 2010Trial
- Association of a SYK promoter polymorphism with SYK expression and IgE-mediated histamine release.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2023Article
- Discovery of Lanraplenib (GS-9876): A Once-Daily Spleen Tyrosine Kinase Inhibitor for Autoimmune Diseases.ACS medicinal chemistry letters · 2020Article
- Identifying regulatory pathways of spleen tyrosine kinase expression in human basophils.The Journal of allergy and clinical immunology · 2020Article
- Modulating the Human Basophil Phenotype During Its Development and Maturation: Basophils Derived from In Vitro Cultures of CD34Methods in molecular biology (Clifton, N.J.) · 2020Article
- Autoantibodies to IgE and FcεRI and the natural variability of spleen tyrosine kinase expression in basophils.The Journal of allergy and clinical immunology · 2019Article
- Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mechanisms.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Stability of Syk protein and mRNA in human peripheral blood basophils.Journal of leukocyte biology · 2016Article
- The relationship between total cellular content of CD203c and cell surface expression on human basophils.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2015Article
- Article
- Use of humanised rat basophilic leukaemia cell line RS-ATL8 for the assessment of allergenicity of Schistosoma mansoni proteins.PLoS neglected tropical diseases · 2014Article
- Roles of basophils and mast cells infiltrating the lung by multiple antigen challenges in asthmatic responses of mice.British journal of pharmacology · 2013Article
- Suppression of the basophil response to allergen during treatment with omalizumab is dependent on 2 competing factors.The Journal of allergy and clinical immunology · 2012Article
- IgE-dependent signaling as a therapeutic target for allergies.Trends in pharmacological sciences · 2012Review
- Expression of CD203c and CD63 in human basophils: relationship to differential regulation of piecemeal and anaphylactic degranulation processes.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2010Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
In human basophils from different subjects, maximum IgE-mediated histamine release and the level of syk protein expression correlate well. It is not clear when in the basophil's lifetime the set-point for syk expression is reached or how expression levels are determined for a given individual. An examination of syk expression in peripheral blood eosinophils, neutrophils, monocytes, B and T cells, DCs, and NK cells showed that with the exception of T cells, basophils were unique in expressing low levels of syk. No correlations were observed between syk expression in basophils and other types of leukocytes, suggesting a unique mechanism of regulation for basophils. The expression level of syk in CD34+ progenitors was approximately 11-fold higher than in peripheral blood basophils, and it remained at this level during maturation of the cells in IL-3 to a cell with characteristics of peripheral blood basophils. Down-regulation of syk expression in the culture-derived basophils was induced by culturing under conditions of chronic aggregation of FcepsilonRI. Syk was down-regulated to peripheral blood basophil levels in 50% of the cells. Despite the chronic aggregation of FcepsilonRI, the cells retained the same expression of FcepsilonRI, histamine content, and morphological staining of granules as cells not experiencing chronic aggregation. These results suggest that chronic stimulation through FcepsilonRI during basophil maturation might be a mechanism for down-regulating syk expression, while retaining other characteristics associated with mature peripheral blood basophils.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.